Telomerase activity, apoptosis and cell cycle progression in ataxia telangiectasia lymphocytes expressing TCL1

C. Gabellini, A. Antonelli, P. Petrinelli, A. Biroccio, L. Marcucci, G. Nigro, G. Russo, G. Zupi, R. Elli

Research output: Contribution to journalArticlepeer-review

Abstract

Individuals affected by ataxia telangiectasia (AT) have a marked susceptibility to cancer. Ataxia telangiectasia cells, in addition to defects in cell cycle checkpoints, show dysfunction of apoptosis and of telomeres, which are both thought to have a role in the progression of malignancy. In 1-5% of patients with AT, clonal expansion of T lymphocytes carrying t(14;14) chromosomal translocation, deregulating TCL1 gene(s), has been described. While it is known that these cells can progress with time to a frank leukaemia, the molecular pathway leading to tumorigenesis has not yet been fully investigated. In this study, we compared AT clonal cells, representing 88% of the entire T lymphocytes (AT94-1) and expressing TCL1 oncogene (ATM- TCL1 +), cell cycle progression to T lymphocytes of AT patients without TCL1 expression (ATM- TCL1-) by analysing their spontaneous apoptosis rate, spontaneous telomerase activity and telomere instability. We show that in ATM- TCL1+ lymphocytes, apoptosis rate and cell cycle progression are restored back to a rate comparable with that observed in normal lymphocytes while telomere dysfunction is maintained.

Original languageEnglish
Pages (from-to)1091-1095
Number of pages5
JournalBritish Journal of Cancer
Volume89
Issue number6
DOIs
Publication statusPublished - Sep 15 2003

Keywords

  • Apoptosis
  • Ataxia telangiectasia
  • Cell cycle
  • TCL1
  • Telomere

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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