Telomerase activity, hTERT expression, and phosphorylation are downregulated in CD4+ T lymphocytes infected with human immunodeficiency virus type 1 (HIV-1)

Ornella Franzese, Riccardo Adamo, Michela Pollicita, Alessandro Comandini, Anastasia Laudisi, Carlo Federico Perno, Stefano Aquaro, Enzo Bonmassar

Research output: Contribution to journalArticlepeer-review

Abstract

Human immunodeficiency virus type 1 (HIV-1) infection is characterized by a progressive decrease of CD4+ T cells accompanied by other immune dysfunctions. Telomerase is transiently activated in lymphocytes during activation and is able to compensate for the progressive telomeric loss that occurs at each cell division, contributing to ensure the telomere length necessary for multiple proliferative events. The effect of HIV-1 infection on telomerase activity and on the expression of some of the factors involved in its regulation in CD4+ T cells was investigated. Telomerase was found to be downregulated in both nuclear and cytoplasmic compartments, together with an impairment of human telomerase reverse transcriptase (hTERT) expression and of the cell machinery involved in hTERT phosporylation.

Original languageEnglish
Pages (from-to)639-646
Number of pages8
JournalJournal of Medical Virology
Volume79
Issue number5
DOIs
Publication statusPublished - May 2007

Keywords

  • Activation
  • CD4
  • HIV-1
  • hTERT
  • Phosphorylation
  • Telomerase

ASJC Scopus subject areas

  • Virology

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