Colorectal cancer (CRC) is the third most commonly diagnosed cancer, with over one million new cases every year. Although improved treatments, increased awareness, and early detection have contributed to prolonged survival, CRC still represents an important cause of cancer-related deaths. CRC is a heterogeneous complex of diseases differing in molecular pathways and biological characteristics, arising through a multistep process; this molecular and biological heterogeneity also accounts for the great clinical variability of the disease. The management of CRC requires a multimodal approach, and many efforts have been made to identify molecular markers able to predict the outcome of CRC patients. Telomerase is a ribonucleoprotein complex containing the catalytic protein telomerase reverse transcriptase (TERT) with telomere-specific reverse transcriptase activity which synthesizes telomere sequences utilizing an internal RNA template. The maintenance of telomere length by telomerase is critical to preserving the replicative potential of cancer cells. Several pieces of evidence suggest that TERT, besides its capacity to extend telomeres, is also involved in other cellular functions, including activation of proliferative signaling pathways and antiapoptotic activity, even by telomere-length-independent mechanisms. In view of its critical role in the oncogenetic process, telomerase may be a molecular marker of neoplastic disease. The aim of this chapter is to analyze literature data in order to assess the role of telomerase expression and/or activity in the carcinogenesis of colorectal cancer and its value as a prognostic marker of disease progression. The potential use of circulating TERT as a biomarker for minimally invasive monitoring of the disease and response to therapy is also discussed.
|Title of host publication||Biomarkers in Disease: Methods, Discoveries and Applications: Biomarkers in Cancer|
|Number of pages||25|
|ISBN (Print)||9789400776814, 9789400776807|
|Publication status||Published - Jan 1 2015|
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)