Telomerase: Cellular immortalization and neoplastic transformation. Multiple functions of a multifaceted complex

C. Belgiovine, I. Chiodi, C. Mondello

Research output: Contribution to journalArticlepeer-review

Abstract

The telomerase complex allows telomere length maintenance, which is required for an unlimited cellular proliferation. Telomerase is virtually absent in normal human somatic cells, which are characterized by a definite proliferation potential, while it is present in the vast majority of tumors (around 90%). Restoring telomerase activity in normal somatic cells can indefinitely prolong cellular life span. However, evidence has been reported that this event can be associated with the acquisition of characteristics typical of cellular transformation. Moreover, analysis of telomerase immortalized cells, as well as of tumor cells in which telomerase is inactivated, has highlighted multiple functions of telomerase in tumorigenesis, besides telomere lengthening. In this paper, we will review telomerase immortalization of somatic cells, together with its possible consequences, and we will examine the complex role of telomerase in tumorigenesis.

Original languageEnglish
Pages (from-to)255-262
Number of pages8
JournalCytogenetic and Genome Research
Volume122
Issue number3-4
DOIs
Publication statusPublished - Feb 2009

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Molecular Biology

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