Telomerase is an independent prognostic marker of overall survival in patients with colorectal cancer

R. Bertorelle, M. Briarava, E. Rampazzo, L. Biasini, M. Agostini, I. Maretto, S. Lonardi, M. L. Friso, C. Mescoli, V. Zagonel, D. Nitti, A. De Rossi, S. Pucciarelli

Research output: Contribution to journalArticle

Abstract

Background:Colorectal cancer (CRC) is an important cause of cancer-related death. Prediction of recurrence is an important issue in the treatment of disease, particularly for stage II patients. The level of telomere-specific reverse transcriptase (hTERT), the catalytic component of the telomerase complex, increases along with CRC progression, but its prognostic value is still unclear.Methods:One hundred and thirty-seven CRC patients were studied for hTERT expression in tumour cells by real-time PCR. hTERT level was evaluated as a prognostic factor of overall survival (OS) in all patients and of disease recurrence in a subgroup of 50 stage II patients.Results:The median hTERT level was 93.8 copies (interquartile range 48-254). Patients with high hTERT levels (above the median) showed a significantly worse survival than those with low hTERT levels (below the median; log-rank test P

Original languageEnglish
Pages (from-to)278-284
Number of pages7
JournalBritish Journal of Cancer
Volume108
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Colorectal cancer
  • hTERT
  • Prognostic marker

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Bertorelle, R., Briarava, M., Rampazzo, E., Biasini, L., Agostini, M., Maretto, I., Lonardi, S., Friso, M. L., Mescoli, C., Zagonel, V., Nitti, D., De Rossi, A., & Pucciarelli, S. (2013). Telomerase is an independent prognostic marker of overall survival in patients with colorectal cancer. British Journal of Cancer, 108(2), 278-284. https://doi.org/10.1038/bjc.2012.602