TELOMERE AND TELOMERASE MODULATION BY BERGAMOT POLYPHENOLIC FRACTION IN EXPERIMENTAL PHOTOAGEING IN HUMAN KERATINOCYTES

S. Nisticò, J. Ehrlich, M. Gliozzi, J. Maiuolo, E. Del Duca, C. Muscoli, V. Mollace

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Abstract

Photoageing represents the addition of extrinsic chronic ultraviolet radiation-induced damage on intrinsic ageing and accounts for most age-associated changes in skin appearance. In this study, we evaluated the effect of 38% BPF, a highly concentrated extract of the bergamot fruit (Citrus bergamia) on UVB-induced photoageing by examining inflammatory cytokine expression, telomere length/telomerase alterations and cellular viability in human immortalized HaCaT keratinocytes. Our results suggest that 38% BPF protects HaCaT cells against UVB-induced oxidative stress and markers of photoageing in a dose-dependent manner and could be a useful supplement in skin care products. Together with antioxidant properties, BPF, a highly concentrated extract of the bergamot fruit, appears to modulate basic cellular signal transduction pathways leading to anti-proliferative, anti-aging and immune modulating responses.

Original languageEnglish
Pages (from-to)723-728
Number of pages6
JournalJournal of Biological Regulators and Homeostatic Agents
Volume29
Issue number3
Publication statusPublished - Jul 1 2015

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nisticò, S., Ehrlich, J., Gliozzi, M., Maiuolo, J., Del Duca, E., Muscoli, C., & Mollace, V. (2015). TELOMERE AND TELOMERASE MODULATION BY BERGAMOT POLYPHENOLIC FRACTION IN EXPERIMENTAL PHOTOAGEING IN HUMAN KERATINOCYTES. Journal of Biological Regulators and Homeostatic Agents, 29(3), 723-728.