Telomere length and telomerase levels delineate subgroups of B-cell chronic lymphocytic leukemia with different biological characteristics and clinical outcomes

Enrica Rampazzo, Laura Bonaldi, Livio Trentin, Carlo Visco, Sonia Keppel, Silvia Giunco, Federica Frezzato, Monica Facco, Elisabetta Novella, Ilaria Giaretta, Paola del Bianco, Gianpietro Semenzato, Anita de Rossi

Research output: Contribution to journalArticle

Abstract

Background B-cell chronic lymphocytic leukemia is a clinically heterogeneous disease; some patients rapidly progress and die within a few years of diagnosis, whereas others have a long life expectancy with minimal or no treatment. Telomere length and telomerase levels have been proposed as prognostic factors; however, very few cases have been characterized for both parameters and no study has analyzed the prognostic value of the telomere/telomerase profile.Design and Methods One hundred and seventy-three cases of chronic lymphocytic leukemia were characterized for telomere lengths and telomerase levels by real-time polymerase chain reaction. Data were correlated with established prognostic markers, IGVH mutational status and chromosomal aberrations, and clinical outcome.Results Telomere lengths were inversely correlated with telomerase levels (rs= -0.213; P=0.012), and most of the cases of chronic lymphocytic leukemia with high levels (above median) of telom-erase had short (below median) telomeres (P=0.0001). Telomerase levels were higher and telomeres were shorter in unmutated IGVH cases than in mutated IGVH ones (P

Original languageEnglish
Pages (from-to)56-63
Number of pages8
JournalHaematologica
Volume97
Issue number1
DOIs
Publication statusPublished - Jan 1 2012

Keywords

  • B-Cll
  • Chromosomal aberrations
  • Telomerase
  • Telomere

ASJC Scopus subject areas

  • Hematology

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