Telomere length and telomerase levels delineate subgroups of B-cell chronic lymphocytic leukemia with different biological characteristics and clinical outcomes

Enrica Rampazzo, Laura Bonaldi, Livio Trentin, Carlo Visco, Sonia Keppel, Silvia Giunco, Federica Frezzato, Monica Facco, Elisabetta Novella, Ilaria Giaretta, Paola del Bianco, Gianpietro Semenzato, Anita de Rossi

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background B-cell chronic lymphocytic leukemia is a clinically heterogeneous disease; some patients rapidly progress and die within a few years of diagnosis, whereas others have a long life expectancy with minimal or no treatment. Telomere length and telomerase levels have been proposed as prognostic factors; however, very few cases have been characterized for both parameters and no study has analyzed the prognostic value of the telomere/telomerase profile.Design and Methods One hundred and seventy-three cases of chronic lymphocytic leukemia were characterized for telomere lengths and telomerase levels by real-time polymerase chain reaction. Data were correlated with established prognostic markers, IGVH mutational status and chromosomal aberrations, and clinical outcome.Results Telomere lengths were inversely correlated with telomerase levels (rs= -0.213; P=0.012), and most of the cases of chronic lymphocytic leukemia with high levels (above median) of telom-erase had short (below median) telomeres (P=0.0001). Telomerase levels were higher and telomeres were shorter in unmutated IGVH cases than in mutated IGVH ones (P

Original languageEnglish
Pages (from-to)56-63
Number of pages8
JournalHaematologica
Volume97
Issue number1
DOIs
Publication statusPublished - Jan 1 2012

Fingerprint

Telomerase
Telomere
B-Cell Chronic Lymphocytic Leukemia
Life Expectancy
Chromosome Aberrations
Real-Time Polymerase Chain Reaction

Keywords

  • B-Cll
  • Chromosomal aberrations
  • Telomerase
  • Telomere

ASJC Scopus subject areas

  • Hematology

Cite this

Telomere length and telomerase levels delineate subgroups of B-cell chronic lymphocytic leukemia with different biological characteristics and clinical outcomes. / Rampazzo, Enrica; Bonaldi, Laura; Trentin, Livio; Visco, Carlo; Keppel, Sonia; Giunco, Silvia; Frezzato, Federica; Facco, Monica; Novella, Elisabetta; Giaretta, Ilaria; del Bianco, Paola; Semenzato, Gianpietro; de Rossi, Anita.

In: Haematologica, Vol. 97, No. 1, 01.01.2012, p. 56-63.

Research output: Contribution to journalArticle

Rampazzo, Enrica ; Bonaldi, Laura ; Trentin, Livio ; Visco, Carlo ; Keppel, Sonia ; Giunco, Silvia ; Frezzato, Federica ; Facco, Monica ; Novella, Elisabetta ; Giaretta, Ilaria ; del Bianco, Paola ; Semenzato, Gianpietro ; de Rossi, Anita. / Telomere length and telomerase levels delineate subgroups of B-cell chronic lymphocytic leukemia with different biological characteristics and clinical outcomes. In: Haematologica. 2012 ; Vol. 97, No. 1. pp. 56-63.
@article{94d8c3698f30483cba0279e3d992ef2a,
title = "Telomere length and telomerase levels delineate subgroups of B-cell chronic lymphocytic leukemia with different biological characteristics and clinical outcomes",
abstract = "Background B-cell chronic lymphocytic leukemia is a clinically heterogeneous disease; some patients rapidly progress and die within a few years of diagnosis, whereas others have a long life expectancy with minimal or no treatment. Telomere length and telomerase levels have been proposed as prognostic factors; however, very few cases have been characterized for both parameters and no study has analyzed the prognostic value of the telomere/telomerase profile.Design and Methods One hundred and seventy-three cases of chronic lymphocytic leukemia were characterized for telomere lengths and telomerase levels by real-time polymerase chain reaction. Data were correlated with established prognostic markers, IGVH mutational status and chromosomal aberrations, and clinical outcome.Results Telomere lengths were inversely correlated with telomerase levels (rs= -0.213; P=0.012), and most of the cases of chronic lymphocytic leukemia with high levels (above median) of telom-erase had short (below median) telomeres (P=0.0001). Telomerase levels were higher and telomeres were shorter in unmutated IGVH cases than in mutated IGVH ones (P",
keywords = "B-Cll, Chromosomal aberrations, Telomerase, Telomere",
author = "Enrica Rampazzo and Laura Bonaldi and Livio Trentin and Carlo Visco and Sonia Keppel and Silvia Giunco and Federica Frezzato and Monica Facco and Elisabetta Novella and Ilaria Giaretta and {del Bianco}, Paola and Gianpietro Semenzato and {de Rossi}, Anita",
year = "2012",
month = "1",
day = "1",
doi = "10.3324/haematol.2011.049874",
language = "English",
volume = "97",
pages = "56--63",
journal = "Haematologica",
issn = "0390-6078",
publisher = "NLM (Medline)",
number = "1",

}

TY - JOUR

T1 - Telomere length and telomerase levels delineate subgroups of B-cell chronic lymphocytic leukemia with different biological characteristics and clinical outcomes

AU - Rampazzo, Enrica

AU - Bonaldi, Laura

AU - Trentin, Livio

AU - Visco, Carlo

AU - Keppel, Sonia

AU - Giunco, Silvia

AU - Frezzato, Federica

AU - Facco, Monica

AU - Novella, Elisabetta

AU - Giaretta, Ilaria

AU - del Bianco, Paola

AU - Semenzato, Gianpietro

AU - de Rossi, Anita

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Background B-cell chronic lymphocytic leukemia is a clinically heterogeneous disease; some patients rapidly progress and die within a few years of diagnosis, whereas others have a long life expectancy with minimal or no treatment. Telomere length and telomerase levels have been proposed as prognostic factors; however, very few cases have been characterized for both parameters and no study has analyzed the prognostic value of the telomere/telomerase profile.Design and Methods One hundred and seventy-three cases of chronic lymphocytic leukemia were characterized for telomere lengths and telomerase levels by real-time polymerase chain reaction. Data were correlated with established prognostic markers, IGVH mutational status and chromosomal aberrations, and clinical outcome.Results Telomere lengths were inversely correlated with telomerase levels (rs= -0.213; P=0.012), and most of the cases of chronic lymphocytic leukemia with high levels (above median) of telom-erase had short (below median) telomeres (P=0.0001). Telomerase levels were higher and telomeres were shorter in unmutated IGVH cases than in mutated IGVH ones (P

AB - Background B-cell chronic lymphocytic leukemia is a clinically heterogeneous disease; some patients rapidly progress and die within a few years of diagnosis, whereas others have a long life expectancy with minimal or no treatment. Telomere length and telomerase levels have been proposed as prognostic factors; however, very few cases have been characterized for both parameters and no study has analyzed the prognostic value of the telomere/telomerase profile.Design and Methods One hundred and seventy-three cases of chronic lymphocytic leukemia were characterized for telomere lengths and telomerase levels by real-time polymerase chain reaction. Data were correlated with established prognostic markers, IGVH mutational status and chromosomal aberrations, and clinical outcome.Results Telomere lengths were inversely correlated with telomerase levels (rs= -0.213; P=0.012), and most of the cases of chronic lymphocytic leukemia with high levels (above median) of telom-erase had short (below median) telomeres (P=0.0001). Telomerase levels were higher and telomeres were shorter in unmutated IGVH cases than in mutated IGVH ones (P

KW - B-Cll

KW - Chromosomal aberrations

KW - Telomerase

KW - Telomere

UR - http://www.scopus.com/inward/record.url?scp=84855215427&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855215427&partnerID=8YFLogxK

U2 - 10.3324/haematol.2011.049874

DO - 10.3324/haematol.2011.049874

M3 - Article

C2 - 21933855

AN - SCOPUS:84855215427

VL - 97

SP - 56

EP - 63

JO - Haematologica

JF - Haematologica

SN - 0390-6078

IS - 1

ER -