Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men: The VA normative aging study

Elena Colicino, Ander Wilson, Maria Chiara Frisardi, Diddier Prada, Melinda C. Power, Mirjam Hoxha, Laura Dioni, Avron Spiro, Pantel S. Vokonas, Marc G. Weisskopf, Joel D. Schwartz, Andrea A. Baccarelli

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Abstract

Background: Long-term air pollution exposure has been associated with age-related cognitive impairment, possibly because of enhanced inflammation. Leukocytes with longer telomere length (TL) are more responsive to inflammatory stimuli, yet TL has not been evaluated in relation to air pollution and cognition. Objectives: We assessed whether TL modifies the association of 1-year exposure to black carbon (BC), a marker of traffic-related air pollution, with cognitive function in older men, and we examined whether this modification is independent of age and of C-reactive protein (CRP), a marker of inflammation. Methods: Between 1999 and 2007, we conducted 1-3 cognitive examinations of 428 older men in the Veterans Affairs (VA) Normative Aging Study. We used covariate-adjusted repeated-measure logistic regression to estimate associations of 1-year BC exposure with relative odds of being a low scorer (≤ 25) on the Mini-Mental State Examination (MMSE), which is a proxy of poor cognition. Confounders included age, CRP, and lifestyle and sociodemographic factors. Results: Each doubling in BC level was associated with 1.57 (95% CI: 1.20, 2.05) times higher odds of low MMSE scores. The BC-MMSE association was greater only among individuals with longer blood TL (5th quintile) (OR = 3.23; 95% CI: 1.37, 7.59; p = 0.04 for BC-by-TLinteraction). TL and CRP were associated neither with each other nor with MMSE. However, CRP modified the BC-MMSE relationship, with stronger associations only at higher CRP (5th quintile) and reference TL level (1st quintile) (OR = 2.68; 95% CI: 1.06, 6.79; p = 0.04 for BC-by-CRP-interaction). Conclusions: TL and CRP levels may help predict the impact of BC exposure on cognitive function in older men.

Original languageEnglish
Pages (from-to)76-81
Number of pages6
JournalEnvironmental Health Perspectives
Volume125
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

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Soot
Telomere
Veterans
Cognition
C-Reactive Protein
Air Pollution
Inflammation
Proxy
Life Style
Leukocytes
Logistic Models
Odds Ratio

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Colicino, E., Wilson, A., Frisardi, M. C., Prada, D., Power, M. C., Hoxha, M., ... Baccarelli, A. A. (2017). Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men: The VA normative aging study. Environmental Health Perspectives, 125(1), 76-81. https://doi.org/10.1289/EHP241

Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men : The VA normative aging study. / Colicino, Elena; Wilson, Ander; Frisardi, Maria Chiara; Prada, Diddier; Power, Melinda C.; Hoxha, Mirjam; Dioni, Laura; Spiro, Avron; Vokonas, Pantel S.; Weisskopf, Marc G.; Schwartz, Joel D.; Baccarelli, Andrea A.

In: Environmental Health Perspectives, Vol. 125, No. 1, 01.01.2017, p. 76-81.

Research output: Contribution to journalArticle

Colicino, E, Wilson, A, Frisardi, MC, Prada, D, Power, MC, Hoxha, M, Dioni, L, Spiro, A, Vokonas, PS, Weisskopf, MG, Schwartz, JD & Baccarelli, AA 2017, 'Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men: The VA normative aging study', Environmental Health Perspectives, vol. 125, no. 1, pp. 76-81. https://doi.org/10.1289/EHP241
Colicino, Elena ; Wilson, Ander ; Frisardi, Maria Chiara ; Prada, Diddier ; Power, Melinda C. ; Hoxha, Mirjam ; Dioni, Laura ; Spiro, Avron ; Vokonas, Pantel S. ; Weisskopf, Marc G. ; Schwartz, Joel D. ; Baccarelli, Andrea A. / Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men : The VA normative aging study. In: Environmental Health Perspectives. 2017 ; Vol. 125, No. 1. pp. 76-81.
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abstract = "Background: Long-term air pollution exposure has been associated with age-related cognitive impairment, possibly because of enhanced inflammation. Leukocytes with longer telomere length (TL) are more responsive to inflammatory stimuli, yet TL has not been evaluated in relation to air pollution and cognition. Objectives: We assessed whether TL modifies the association of 1-year exposure to black carbon (BC), a marker of traffic-related air pollution, with cognitive function in older men, and we examined whether this modification is independent of age and of C-reactive protein (CRP), a marker of inflammation. Methods: Between 1999 and 2007, we conducted 1-3 cognitive examinations of 428 older men in the Veterans Affairs (VA) Normative Aging Study. We used covariate-adjusted repeated-measure logistic regression to estimate associations of 1-year BC exposure with relative odds of being a low scorer (≤ 25) on the Mini-Mental State Examination (MMSE), which is a proxy of poor cognition. Confounders included age, CRP, and lifestyle and sociodemographic factors. Results: Each doubling in BC level was associated with 1.57 (95{\%} CI: 1.20, 2.05) times higher odds of low MMSE scores. The BC-MMSE association was greater only among individuals with longer blood TL (5th quintile) (OR = 3.23; 95{\%} CI: 1.37, 7.59; p = 0.04 for BC-by-TLinteraction). TL and CRP were associated neither with each other nor with MMSE. However, CRP modified the BC-MMSE relationship, with stronger associations only at higher CRP (5th quintile) and reference TL level (1st quintile) (OR = 2.68; 95{\%} CI: 1.06, 6.79; p = 0.04 for BC-by-CRP-interaction). Conclusions: TL and CRP levels may help predict the impact of BC exposure on cognitive function in older men.",
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T1 - Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men

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AU - Colicino, Elena

AU - Wilson, Ander

AU - Frisardi, Maria Chiara

AU - Prada, Diddier

AU - Power, Melinda C.

AU - Hoxha, Mirjam

AU - Dioni, Laura

AU - Spiro, Avron

AU - Vokonas, Pantel S.

AU - Weisskopf, Marc G.

AU - Schwartz, Joel D.

AU - Baccarelli, Andrea A.

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N2 - Background: Long-term air pollution exposure has been associated with age-related cognitive impairment, possibly because of enhanced inflammation. Leukocytes with longer telomere length (TL) are more responsive to inflammatory stimuli, yet TL has not been evaluated in relation to air pollution and cognition. Objectives: We assessed whether TL modifies the association of 1-year exposure to black carbon (BC), a marker of traffic-related air pollution, with cognitive function in older men, and we examined whether this modification is independent of age and of C-reactive protein (CRP), a marker of inflammation. Methods: Between 1999 and 2007, we conducted 1-3 cognitive examinations of 428 older men in the Veterans Affairs (VA) Normative Aging Study. We used covariate-adjusted repeated-measure logistic regression to estimate associations of 1-year BC exposure with relative odds of being a low scorer (≤ 25) on the Mini-Mental State Examination (MMSE), which is a proxy of poor cognition. Confounders included age, CRP, and lifestyle and sociodemographic factors. Results: Each doubling in BC level was associated with 1.57 (95% CI: 1.20, 2.05) times higher odds of low MMSE scores. The BC-MMSE association was greater only among individuals with longer blood TL (5th quintile) (OR = 3.23; 95% CI: 1.37, 7.59; p = 0.04 for BC-by-TLinteraction). TL and CRP were associated neither with each other nor with MMSE. However, CRP modified the BC-MMSE relationship, with stronger associations only at higher CRP (5th quintile) and reference TL level (1st quintile) (OR = 2.68; 95% CI: 1.06, 6.79; p = 0.04 for BC-by-CRP-interaction). Conclusions: TL and CRP levels may help predict the impact of BC exposure on cognitive function in older men.

AB - Background: Long-term air pollution exposure has been associated with age-related cognitive impairment, possibly because of enhanced inflammation. Leukocytes with longer telomere length (TL) are more responsive to inflammatory stimuli, yet TL has not been evaluated in relation to air pollution and cognition. Objectives: We assessed whether TL modifies the association of 1-year exposure to black carbon (BC), a marker of traffic-related air pollution, with cognitive function in older men, and we examined whether this modification is independent of age and of C-reactive protein (CRP), a marker of inflammation. Methods: Between 1999 and 2007, we conducted 1-3 cognitive examinations of 428 older men in the Veterans Affairs (VA) Normative Aging Study. We used covariate-adjusted repeated-measure logistic regression to estimate associations of 1-year BC exposure with relative odds of being a low scorer (≤ 25) on the Mini-Mental State Examination (MMSE), which is a proxy of poor cognition. Confounders included age, CRP, and lifestyle and sociodemographic factors. Results: Each doubling in BC level was associated with 1.57 (95% CI: 1.20, 2.05) times higher odds of low MMSE scores. The BC-MMSE association was greater only among individuals with longer blood TL (5th quintile) (OR = 3.23; 95% CI: 1.37, 7.59; p = 0.04 for BC-by-TLinteraction). TL and CRP were associated neither with each other nor with MMSE. However, CRP modified the BC-MMSE relationship, with stronger associations only at higher CRP (5th quintile) and reference TL level (1st quintile) (OR = 2.68; 95% CI: 1.06, 6.79; p = 0.04 for BC-by-CRP-interaction). Conclusions: TL and CRP levels may help predict the impact of BC exposure on cognitive function in older men.

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