Telomere/telomerase system: A new target of statins pleiotropic effect?

Research output: Contribution to journalArticle

Abstract

Statins are well established drugs for primary and secondary prevention of coronary artery disease (CAD). Despite the well-known ability of statins to lower cholesterol, it is now clear that clinical benefits are also substantially higher than expected and several clinical trials, like JUPITER (Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin trial) have indicated that such clinical effects are independent of cholesterol reduction. These cholesterol-independent actions have been named "pleiotropic effects" and include: anti-oxidation and anti-inflammatory effects, modulation of immune activation, stabilization of atherosclerotic plaque, decreased platelet activation, inhibition of cardiac hypertrophy, reduction of cytokine-mediated vascular smooth muscle cell (VSMC) proliferation and improvement of endothelial function. Recently, additional pleiotropic effects of statins on "cellular senescence" have been seen in different cell types, including endothelial progenitor cells (EPC), endothelial cells (EC), VSMC and chondrocytes. At the molecular level, the effect of statins on cellular senescence could be mediated by their interaction with the telomere/telomerase system. Recent evidence suggests that the anti-aging effects of statins are linked to their ability to inhibit telomere shortening by reducing either directly and indirectly oxidative telomeric DNA damage, as well as by a telomere capping proteins dependent mechanism. In this review, we discuss the pleiotropic effects of statins, focusing on the telomere/telomerase system. We will also present our current findings regarding leukocyte telomere length in very old people with myocardial infarction on statin therapy.

Original languageEnglish
Pages (from-to)216-224
Number of pages9
JournalCurrent Vascular Pharmacology
Volume10
Issue number2
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Telomerase
Telomere
Cell Aging
Cholesterol
Primary Prevention
Vascular Smooth Muscle
Smooth Muscle Myocytes
Telomere Shortening
Platelet Activation
Cardiomegaly
Atherosclerotic Plaques
Chondrocytes
Secondary Prevention
DNA Damage
Coronary Artery Disease
Leukocytes
Anti-Inflammatory Agents
Endothelial Cells
Myocardial Infarction

Keywords

  • Statins
  • Telomerase
  • Telomeres

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Telomere/telomerase system : A new target of statins pleiotropic effect? / Olivieri, Fabiola; Mazzanti, Ilaria; Abbatecola, Angela M.; Recchioni, Rina; Marcheselli, Fiorella; Procopio, Antonio D.; Antonicelli, Roberto.

In: Current Vascular Pharmacology, Vol. 10, No. 2, 03.2012, p. 216-224.

Research output: Contribution to journalArticle

@article{d261b3aee5cb4a6cadce95966e1b61c9,
title = "Telomere/telomerase system: A new target of statins pleiotropic effect?",
abstract = "Statins are well established drugs for primary and secondary prevention of coronary artery disease (CAD). Despite the well-known ability of statins to lower cholesterol, it is now clear that clinical benefits are also substantially higher than expected and several clinical trials, like JUPITER (Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin trial) have indicated that such clinical effects are independent of cholesterol reduction. These cholesterol-independent actions have been named {"}pleiotropic effects{"} and include: anti-oxidation and anti-inflammatory effects, modulation of immune activation, stabilization of atherosclerotic plaque, decreased platelet activation, inhibition of cardiac hypertrophy, reduction of cytokine-mediated vascular smooth muscle cell (VSMC) proliferation and improvement of endothelial function. Recently, additional pleiotropic effects of statins on {"}cellular senescence{"} have been seen in different cell types, including endothelial progenitor cells (EPC), endothelial cells (EC), VSMC and chondrocytes. At the molecular level, the effect of statins on cellular senescence could be mediated by their interaction with the telomere/telomerase system. Recent evidence suggests that the anti-aging effects of statins are linked to their ability to inhibit telomere shortening by reducing either directly and indirectly oxidative telomeric DNA damage, as well as by a telomere capping proteins dependent mechanism. In this review, we discuss the pleiotropic effects of statins, focusing on the telomere/telomerase system. We will also present our current findings regarding leukocyte telomere length in very old people with myocardial infarction on statin therapy.",
keywords = "Statins, Telomerase, Telomeres",
author = "Fabiola Olivieri and Ilaria Mazzanti and Abbatecola, {Angela M.} and Rina Recchioni and Fiorella Marcheselli and Procopio, {Antonio D.} and Roberto Antonicelli",
year = "2012",
month = "3",
doi = "10.2174/157016112799305076",
language = "English",
volume = "10",
pages = "216--224",
journal = "Current Vascular Pharmacology",
issn = "1570-1611",
publisher = "Bentham Science Publishers B.V.",
number = "2",

}

TY - JOUR

T1 - Telomere/telomerase system

T2 - A new target of statins pleiotropic effect?

AU - Olivieri, Fabiola

AU - Mazzanti, Ilaria

AU - Abbatecola, Angela M.

AU - Recchioni, Rina

AU - Marcheselli, Fiorella

AU - Procopio, Antonio D.

AU - Antonicelli, Roberto

PY - 2012/3

Y1 - 2012/3

N2 - Statins are well established drugs for primary and secondary prevention of coronary artery disease (CAD). Despite the well-known ability of statins to lower cholesterol, it is now clear that clinical benefits are also substantially higher than expected and several clinical trials, like JUPITER (Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin trial) have indicated that such clinical effects are independent of cholesterol reduction. These cholesterol-independent actions have been named "pleiotropic effects" and include: anti-oxidation and anti-inflammatory effects, modulation of immune activation, stabilization of atherosclerotic plaque, decreased platelet activation, inhibition of cardiac hypertrophy, reduction of cytokine-mediated vascular smooth muscle cell (VSMC) proliferation and improvement of endothelial function. Recently, additional pleiotropic effects of statins on "cellular senescence" have been seen in different cell types, including endothelial progenitor cells (EPC), endothelial cells (EC), VSMC and chondrocytes. At the molecular level, the effect of statins on cellular senescence could be mediated by their interaction with the telomere/telomerase system. Recent evidence suggests that the anti-aging effects of statins are linked to their ability to inhibit telomere shortening by reducing either directly and indirectly oxidative telomeric DNA damage, as well as by a telomere capping proteins dependent mechanism. In this review, we discuss the pleiotropic effects of statins, focusing on the telomere/telomerase system. We will also present our current findings regarding leukocyte telomere length in very old people with myocardial infarction on statin therapy.

AB - Statins are well established drugs for primary and secondary prevention of coronary artery disease (CAD). Despite the well-known ability of statins to lower cholesterol, it is now clear that clinical benefits are also substantially higher than expected and several clinical trials, like JUPITER (Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin trial) have indicated that such clinical effects are independent of cholesterol reduction. These cholesterol-independent actions have been named "pleiotropic effects" and include: anti-oxidation and anti-inflammatory effects, modulation of immune activation, stabilization of atherosclerotic plaque, decreased platelet activation, inhibition of cardiac hypertrophy, reduction of cytokine-mediated vascular smooth muscle cell (VSMC) proliferation and improvement of endothelial function. Recently, additional pleiotropic effects of statins on "cellular senescence" have been seen in different cell types, including endothelial progenitor cells (EPC), endothelial cells (EC), VSMC and chondrocytes. At the molecular level, the effect of statins on cellular senescence could be mediated by their interaction with the telomere/telomerase system. Recent evidence suggests that the anti-aging effects of statins are linked to their ability to inhibit telomere shortening by reducing either directly and indirectly oxidative telomeric DNA damage, as well as by a telomere capping proteins dependent mechanism. In this review, we discuss the pleiotropic effects of statins, focusing on the telomere/telomerase system. We will also present our current findings regarding leukocyte telomere length in very old people with myocardial infarction on statin therapy.

KW - Statins

KW - Telomerase

KW - Telomeres

UR - http://www.scopus.com/inward/record.url?scp=84857134035&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857134035&partnerID=8YFLogxK

U2 - 10.2174/157016112799305076

DO - 10.2174/157016112799305076

M3 - Article

C2 - 22022767

AN - SCOPUS:84857134035

VL - 10

SP - 216

EP - 224

JO - Current Vascular Pharmacology

JF - Current Vascular Pharmacology

SN - 1570-1611

IS - 2

ER -