TEM-72, a new extended-spectrum β-lactamase detected in Proteus mirabilis and Morganella morganii in Italy

M. Perilli, B. Segatore, M. R. De Massis, M. L. Riccio, C. Bianchi, A. Zollo, G. M. Rossolini, G. Amicosante

Research output: Contribution to journalArticlepeer-review

Abstract

A new natural TEM-2 derivative, named TEM-72, was identified in a Proteus mirabilis strain and in a Morganella morganii strain isolated in Italy in 1999. Compared to TEM-1, TEM-72 contains the following amino acid substitutions: Q39K, M182T, G238S, and E240K. Kinetic analysis showed that TEM-72 exhibits an extended-spectrum activity, including activity against oxyimino-cephalosporins and aztreonam. Expression of bla(TEM-72) in Escherichia coli was capable of decreasing the host susceptibility to the above drugs.

Original languageEnglish
Pages (from-to)2537-2539
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume44
Issue number9
DOIs
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Pharmacology (medical)

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