TY - JOUR
T1 - TEM-72, a new extended-spectrum β-lactamase detected in Proteus mirabilis and Morganella morganii in Italy
AU - Perilli, M.
AU - Segatore, B.
AU - De Massis, M. R.
AU - Riccio, M. L.
AU - Bianchi, C.
AU - Zollo, A.
AU - Rossolini, G. M.
AU - Amicosante, G.
PY - 2000
Y1 - 2000
N2 - A new natural TEM-2 derivative, named TEM-72, was identified in a Proteus mirabilis strain and in a Morganella morganii strain isolated in Italy in 1999. Compared to TEM-1, TEM-72 contains the following amino acid substitutions: Q39K, M182T, G238S, and E240K. Kinetic analysis showed that TEM-72 exhibits an extended-spectrum activity, including activity against oxyimino-cephalosporins and aztreonam. Expression of bla(TEM-72) in Escherichia coli was capable of decreasing the host susceptibility to the above drugs.
AB - A new natural TEM-2 derivative, named TEM-72, was identified in a Proteus mirabilis strain and in a Morganella morganii strain isolated in Italy in 1999. Compared to TEM-1, TEM-72 contains the following amino acid substitutions: Q39K, M182T, G238S, and E240K. Kinetic analysis showed that TEM-72 exhibits an extended-spectrum activity, including activity against oxyimino-cephalosporins and aztreonam. Expression of bla(TEM-72) in Escherichia coli was capable of decreasing the host susceptibility to the above drugs.
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U2 - 10.1128/AAC.44.9.2537-2539.2000
DO - 10.1128/AAC.44.9.2537-2539.2000
M3 - Article
C2 - 10952610
AN - SCOPUS:0033840170
VL - 44
SP - 2537
EP - 2539
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 9
ER -