Temozolomide and radiotherapy versus radiotherapy alone in high grade gliomas: A very long term comparative study and literature review

Salvatore Parisi, Pietro Corsa, Arcangela Raguso, Antonio Perrone, Sabrina Cossa, Tindara Munafò, Gerardo Sanpaolo, Elisa Donno, Maria Antonietta Clemente, Michele Piombino, Federico Parisi, Guido Valle

Research output: Contribution to journalArticlepeer-review

Abstract

Temozolomide (TMZ) is the first line drug in the care of high grade gliomas. The combined treatment of TMZ plus radiotherapy is more effective in the care of brain gliomas then radiotherapy alone. Aim of this report is a survival comparison, on a long time (>10 years) span, of glioma patients treated with radiotherapy alone and with radiotherapy + TMZ. Materials and Methods. In this report we retrospectively reviewed the outcome of 128 consecutive pts with diagnosis of high grade gliomas referred to our institutions from April 1994 to November 2001. The first 64 pts were treated with RT alone and the other 64 with a combination of RT and adjuvant or concomitant TMZ. Results. Grade 3 (G3) haematological toxicity was recorded in 6 (9%) of 64 pts treated with RT and TMZ. No G4 haematological toxicity was observed. Age, histology, and administration of TMZ were statistically significant prognostic factors associated with 2 years overall survival (OS). PFS was for GBM 9 months, for AA 11. Conclusions. The combination of RT and TMZ improves long term survival in glioma patients. Our results confirm the superiority of the combination on a long time basis.

Original languageEnglish
Article number620643
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Fingerprint Dive into the research topics of 'Temozolomide and radiotherapy versus radiotherapy alone in high grade gliomas: A very long term comparative study and literature review'. Together they form a unique fingerprint.

Cite this