TY - JOUR
T1 - Temozolomide-induced partial response in a patient with primary diffuse leptomeningeal gliomatosis
AU - Franceschi, Enrico
AU - Cavallo, Giovanna
AU - Scopece, Luciano
AU - Degli Esposti, Roberta
AU - Paioli, Gabriele
AU - Paioli, Anna
AU - Palmerini, Emanuela
AU - Foschini, Maria Pia
AU - Marliani, Anna Federica
AU - Crinò, Lucio
PY - 2005/7
Y1 - 2005/7
N2 - Herein we describe the case of a patient with primary diffuse leptomeningeal gliomatosis (PDLG). After surgery and ventriculoperitoneal shunt placement, due to poor general conditions, the patient was not eligible for radiotherapy. For this reason we decided to start a systemic chemotherapy treatment with Temozolomide (150 mg/m2 per day for 5 days every 4 weeks). After three cycles a partial response was achieved with a clear improvement of general conditions. In our knowledge, this is the first time that PDLG treatment with Temozolomide has been described.
AB - Herein we describe the case of a patient with primary diffuse leptomeningeal gliomatosis (PDLG). After surgery and ventriculoperitoneal shunt placement, due to poor general conditions, the patient was not eligible for radiotherapy. For this reason we decided to start a systemic chemotherapy treatment with Temozolomide (150 mg/m2 per day for 5 days every 4 weeks). After three cycles a partial response was achieved with a clear improvement of general conditions. In our knowledge, this is the first time that PDLG treatment with Temozolomide has been described.
KW - Chemotherapy
KW - Primary diffuse leptomeningeal gliomatosis
KW - Temozolomide
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U2 - 10.1007/s11060-004-5672-5
DO - 10.1007/s11060-004-5672-5
M3 - Article
C2 - 15980977
AN - SCOPUS:22144461023
VL - 73
SP - 261
EP - 264
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
SN - 0167-594X
IS - 3
ER -