Abstract
Background:: personality features have been repeatedly associated with depression treatment outcome in Major Depressive Disorder (MDD), however conclusive results are still lacking. Moreover, as for Bipolar Disorder (BD), results are only few and preliminary. Aim:: the aim of the present study was to perform an exploratory investigation of the influence of personality traits as assessed by the Temperament and Character Inventory (TCI), on principal depression treatment outcomes (non remission, non response and resistance). Methods:: 743 mood disorders patients (455 MDD (61.24%) and 288 BD (38.76%)) were recruited in the context of 6 European studies. Generalized logit models were performed to test the effects of TCI dimensions on treatment outcomes, considering possible confounders such as age, gender and education. Positive results were controlled for comorbidities (anxiety and substance use disorders) as well. Results:: MDD Non-Remitters showed high Harm Avoidance (HA) and Self Transcendence (ST) (p = 0.0004, d = 0.40; p = 0.007, d = 0.36 respectively) and low Persistence (P) and Self Directedness (SD) (p = 0.05; d = 0.18; p = 0.002, d = 0.40, respectively); MDD Non-Responders showed a slightly different profile with high HA and low Reward Dependence (RD) and SD; finally, MDD Resistants showed low RD, P and Cooperativeness (C). In BD patients, only higher HA in non response was observed. Limitations:: the retrospective cross-sectional design, the TCI assessment regardless of the mood state and the small number of bipolar patients represent the main limitations. Conclusion:: specific TCI personality traits are associated with depression treatment outcome in MDD patients. The inclusion of such personality traits, together with other socio-demographic and clinical predictors, could ameliorate the accuracy of the prediction models available to date.
| Original language | English |
|---|---|
| Pages (from-to) | 464-474 |
| Number of pages | 11 |
| Journal | Journal of Affective Disorders |
| Volume | 252 |
| DOIs | |
| Publication status | Published - Jun 1 2019 |
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Keywords
- Bipolar disorder
- Major depressive disorder
- Treatment outcomes
- Treatment resistance depression
ASJC Scopus subject areas
- Clinical Psychology
- Psychiatry and Mental health
Cite this
Temperament and character influence on depression treatment outcome. / Balestri, Martina; Porcelli, Stefano; Souery, Daniel; Kasper, Siegfried; Dikeos, Dimitris; Ferentinos, Panagiotis; Papadimitriou, George N.; Rujescu, Dan; Martinotti, Giovanni; Nicola, Marco Di; Janiri, Luigi; Caletti, Elisabetta; Mandolini, Gian Mario; Pigoni, Alessandro; Paoli, Riccardo Augusto; Lazzaretti, Matteo; Brambilla, Paolo; Sala, Michela; Abbiati, Vera; Bellani, Marcella; Perlini, Cinzia; Rossetti, Maria Gloria; Piccin, Sara; Bonivento, Carolina; Fabbro, Dora; Damante, Giuseppe; Ferrari, Clarissa; Rossi, Roberta; Pedrini, Laura; Benedetti, Francesco; Montgomery, Stuart; Zohar, Joseph; Mendlewicz, Julien; Serretti, Alessandro.
In: Journal of Affective Disorders, Vol. 252, 01.06.2019, p. 464-474.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Temperament and character influence on depression treatment outcome
AU - Balestri, Martina
AU - Porcelli, Stefano
AU - Souery, Daniel
AU - Kasper, Siegfried
AU - Dikeos, Dimitris
AU - Ferentinos, Panagiotis
AU - Papadimitriou, George N.
AU - Rujescu, Dan
AU - Martinotti, Giovanni
AU - Nicola, Marco Di
AU - Janiri, Luigi
AU - Caletti, Elisabetta
AU - Mandolini, Gian Mario
AU - Pigoni, Alessandro
AU - Paoli, Riccardo Augusto
AU - Lazzaretti, Matteo
AU - Brambilla, Paolo
AU - Sala, Michela
AU - Abbiati, Vera
AU - Bellani, Marcella
AU - Perlini, Cinzia
AU - Rossetti, Maria Gloria
AU - Piccin, Sara
AU - Bonivento, Carolina
AU - Fabbro, Dora
AU - Damante, Giuseppe
AU - Ferrari, Clarissa
AU - Rossi, Roberta
AU - Pedrini, Laura
AU - Benedetti, Francesco
AU - Montgomery, Stuart
AU - Zohar, Joseph
AU - Mendlewicz, Julien
AU - Serretti, Alessandro
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Background:: personality features have been repeatedly associated with depression treatment outcome in Major Depressive Disorder (MDD), however conclusive results are still lacking. Moreover, as for Bipolar Disorder (BD), results are only few and preliminary. Aim:: the aim of the present study was to perform an exploratory investigation of the influence of personality traits as assessed by the Temperament and Character Inventory (TCI), on principal depression treatment outcomes (non remission, non response and resistance). Methods:: 743 mood disorders patients (455 MDD (61.24%) and 288 BD (38.76%)) were recruited in the context of 6 European studies. Generalized logit models were performed to test the effects of TCI dimensions on treatment outcomes, considering possible confounders such as age, gender and education. Positive results were controlled for comorbidities (anxiety and substance use disorders) as well. Results:: MDD Non-Remitters showed high Harm Avoidance (HA) and Self Transcendence (ST) (p = 0.0004, d = 0.40; p = 0.007, d = 0.36 respectively) and low Persistence (P) and Self Directedness (SD) (p = 0.05; d = 0.18; p = 0.002, d = 0.40, respectively); MDD Non-Responders showed a slightly different profile with high HA and low Reward Dependence (RD) and SD; finally, MDD Resistants showed low RD, P and Cooperativeness (C). In BD patients, only higher HA in non response was observed. Limitations:: the retrospective cross-sectional design, the TCI assessment regardless of the mood state and the small number of bipolar patients represent the main limitations. Conclusion:: specific TCI personality traits are associated with depression treatment outcome in MDD patients. The inclusion of such personality traits, together with other socio-demographic and clinical predictors, could ameliorate the accuracy of the prediction models available to date.
AB - Background:: personality features have been repeatedly associated with depression treatment outcome in Major Depressive Disorder (MDD), however conclusive results are still lacking. Moreover, as for Bipolar Disorder (BD), results are only few and preliminary. Aim:: the aim of the present study was to perform an exploratory investigation of the influence of personality traits as assessed by the Temperament and Character Inventory (TCI), on principal depression treatment outcomes (non remission, non response and resistance). Methods:: 743 mood disorders patients (455 MDD (61.24%) and 288 BD (38.76%)) were recruited in the context of 6 European studies. Generalized logit models were performed to test the effects of TCI dimensions on treatment outcomes, considering possible confounders such as age, gender and education. Positive results were controlled for comorbidities (anxiety and substance use disorders) as well. Results:: MDD Non-Remitters showed high Harm Avoidance (HA) and Self Transcendence (ST) (p = 0.0004, d = 0.40; p = 0.007, d = 0.36 respectively) and low Persistence (P) and Self Directedness (SD) (p = 0.05; d = 0.18; p = 0.002, d = 0.40, respectively); MDD Non-Responders showed a slightly different profile with high HA and low Reward Dependence (RD) and SD; finally, MDD Resistants showed low RD, P and Cooperativeness (C). In BD patients, only higher HA in non response was observed. Limitations:: the retrospective cross-sectional design, the TCI assessment regardless of the mood state and the small number of bipolar patients represent the main limitations. Conclusion:: specific TCI personality traits are associated with depression treatment outcome in MDD patients. The inclusion of such personality traits, together with other socio-demographic and clinical predictors, could ameliorate the accuracy of the prediction models available to date.
KW - Bipolar disorder
KW - Major depressive disorder
KW - Treatment outcomes
KW - Treatment resistance depression
UR - http://www.scopus.com/inward/record.url?scp=85064311807&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064311807&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2019.04.031
DO - 10.1016/j.jad.2019.04.031
M3 - Article
AN - SCOPUS:85064311807
VL - 252
SP - 464
EP - 474
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -