Temperature dependence of intraparenchymal bronchial blood flow

Piergiuseppe Agostoni, Mark E. Deffebach, Wayne Kirk, George L. Brengelmann

Research output: Contribution to journalArticle

Abstract

Previous studies suggested that bronchial vascular resistance, like that of the skin, changes with the temperature of the surrounding tissue. To investigate this phenomenon, we recorded anastomotic (systemic to pulmonary) (brs-p) and total (br) bronchial blood flow over a temperature range centered on normal. In 7 open-chested dogs the in situ left lower lobe (LLL) was separately ventilated (30 °C, 5% CO2 in humidified air) and was suspended in a fabric net from a strain gauge for continuous recording of weight. The pulmonary circulation of the LLL was pump-perfused at 255 ± 69 ml/min in a closed circuit with temperature set at 30, 33, 36, 39 and 42 °C. brs-p was measured as overflow from the LLL vascular circuit corrected for LLL weight changes. br, tracheal, mid-esophageal and coronary flow were measured with 15 μ radiolabelled microspheres injected in the left atrium. The animal's core temperature and that of the humidified air around the LLL were held constant. br and brs-p were equal and reached a peak at 36 °C with lower levels of flow at higher and lower temperatures. Esophageal, tracheal and coronary flow and cardiac output did not change nor did pressures in the systemic and LLL pulmonary artery and in the LLL airways. An intralobar change in temperature above or below 36 °C decreases only the lobar bronchial blood flow and does not influence blood flow to other nearby tissues including those vascularized by the bronchial circulation.

Original languageEnglish
Pages (from-to)259-267
Number of pages9
JournalRespiration Physiology
Volume68
Issue number3
DOIs
Publication statusPublished - 1987

Keywords

  • Dog
  • Esophageal blood flow
  • Left lower lobe
  • Microspheres
  • Tracheal blood flow

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

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