Temporal changes in standard and tissue doppler imaging echocardiographic parameters after anthracycline chemotherapy in women with breast cancer

Marzia Lotrionte, Elena Cavarretta, Antonio Abbate, Eleonora Mezzaroma, Eugenia De Marco, Silvia Di Persio, Francesco Loperfido, Giuseppe Biondi-Zoccai, Giacomo Frati, Giovanni Palazzoni

Research output: Contribution to journalArticle

Abstract

Anthracyclines are established cardiotoxic agents; however, the exact extent and time course of such cardiotoxicity has not been appraised in detail. We aimed to exploit serial measurements of standard and tissue Doppler imaging (TDI) echocardiographic parameters collected in a prospective clinical trial to clarify the outlook of cardiac function during and long after anthracycline chemotherapy. Women enrolled in a randomized trial focusing on liposomal doxorubicin-based chemotherapy for breast cancer and providing ≥4 separate echocardiographic assessments were included. Repeat-measure nonparametric analyses were used to appraise changes over time in the standard and tissue Doppler imaging echocardiographic parameters. A total of 39 patients with serial imaging evaluations were enrolled. Significant temporal changes were found for the left ventricular ejection fraction and diastolic parameters, despite different temporal trends. Specifically, the left ventricular ejection fraction exhibited a V-shaped trend, decreasing initially from 63% to 61% but then recovering to 64% (p

Original languageEnglish
Pages (from-to)1005-1012
Number of pages8
JournalThe American Journal of Cardiology
Volume112
Issue number7
DOIs
Publication statusPublished - Oct 1 2013

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Lotrionte, M., Cavarretta, E., Abbate, A., Mezzaroma, E., De Marco, E., Di Persio, S., Loperfido, F., Biondi-Zoccai, G., Frati, G., & Palazzoni, G. (2013). Temporal changes in standard and tissue doppler imaging echocardiographic parameters after anthracycline chemotherapy in women with breast cancer. The American Journal of Cardiology, 112(7), 1005-1012. https://doi.org/10.1016/j.amjcard.2013.05.038