Temporal characterization of drug resistance associated mutations in HIV-1 protease and reverse transcriptase in patients failing antiretroviral therapy

Maria Mercedes Santoro, Valentina Svicher, Caterina Gori, Mauro Zaccarelli, Valerio Tozzi, Federica Forbici, Roberta D'Arrigo, Maria Paola Trotta, Maria Concetta Bellocchi, Ubaldo Visco-Comandini, Alessandra Cenci, Ada Bertoli, Pasquale Narciso, Andrea Antinori, Carlo Federico Perno, Francesca Ceccherini-Silberstein

Research output: Contribution to journalArticle

Abstract

The aim of this study was to evaluate the prevalence of genotypic resistance for each drug-class, and of single resistance-mutations in 1,075 HIV-1 infected multi-treated patients undergoing their first genotypic resistance-test (GRT) after virological failure, over the years 1999-2003. First GRT was requested in 2003 for patients at earlier stages of failure, with less advanced disease, higher CD4-cell-count, lower HIV-RNA, and lower drug-experience with respect to 1999. Prevalence of resistance to all three drug-classes decreased from 33.3% in 1999 to 14.8% in 2003 (p

Original languageEnglish
Pages (from-to)89-100
Number of pages12
JournalNew Microbiologica
Volume29
Issue number2
Publication statusPublished - Apr 2006

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Drug Resistance
Mutation
CD4 Lymphocyte Count
Pharmaceutical Preparations
HIV-1
HIV
RNA
Therapeutics
Human immunodeficiency virus 1 p16 protease
Human immunodeficiency virus 1 reverse transcriptase

Keywords

  • Antiviral therapy
  • Genotypic test
  • HIV-1
  • Resistance

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Temporal characterization of drug resistance associated mutations in HIV-1 protease and reverse transcriptase in patients failing antiretroviral therapy. / Santoro, Maria Mercedes; Svicher, Valentina; Gori, Caterina; Zaccarelli, Mauro; Tozzi, Valerio; Forbici, Federica; D'Arrigo, Roberta; Trotta, Maria Paola; Bellocchi, Maria Concetta; Visco-Comandini, Ubaldo; Cenci, Alessandra; Bertoli, Ada; Narciso, Pasquale; Antinori, Andrea; Perno, Carlo Federico; Ceccherini-Silberstein, Francesca.

In: New Microbiologica, Vol. 29, No. 2, 04.2006, p. 89-100.

Research output: Contribution to journalArticle

Santoro, MM, Svicher, V, Gori, C, Zaccarelli, M, Tozzi, V, Forbici, F, D'Arrigo, R, Trotta, MP, Bellocchi, MC, Visco-Comandini, U, Cenci, A, Bertoli, A, Narciso, P, Antinori, A, Perno, CF & Ceccherini-Silberstein, F 2006, 'Temporal characterization of drug resistance associated mutations in HIV-1 protease and reverse transcriptase in patients failing antiretroviral therapy', New Microbiologica, vol. 29, no. 2, pp. 89-100.
Santoro, Maria Mercedes ; Svicher, Valentina ; Gori, Caterina ; Zaccarelli, Mauro ; Tozzi, Valerio ; Forbici, Federica ; D'Arrigo, Roberta ; Trotta, Maria Paola ; Bellocchi, Maria Concetta ; Visco-Comandini, Ubaldo ; Cenci, Alessandra ; Bertoli, Ada ; Narciso, Pasquale ; Antinori, Andrea ; Perno, Carlo Federico ; Ceccherini-Silberstein, Francesca. / Temporal characterization of drug resistance associated mutations in HIV-1 protease and reverse transcriptase in patients failing antiretroviral therapy. In: New Microbiologica. 2006 ; Vol. 29, No. 2. pp. 89-100.
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