Temporal Components of the Motor Patterns Expressed by the Human Spinal Cord Reflect Foot Kinematics

Yuri P. Ivanenko, Renato Grasso, Myrka Zago, Marco Molinari, Giorgio Scivoletto, Vincenzo Castellano, Velio Macellari, Francesco Lacquaniti

Research output: Contribution to journalArticle

Abstract

What are the building blocks with which the human spinal cord constructs the motor patterns of locomotion? In principle, they could correspond to each individual activity pattern in dozens of different muscles. Alternatively, there could exist a small set of constituent temporal components that are common to all activation patterns and reflect global kinematic goals. To address this issue, we studied patients with spinal injury trained to step on a treadmill with body weight support. Patients learned to produce foot kinematics similar to that of healthy subjects but with activity patterns of individual muscles generally different from the control group. Hidden in the muscle patterns, we found a basic set of five temporal components, whose flexible combination accounted for the wide range of muscle patterns recorded in both controls and patients. Furthermore, two of the components were systematically related to foot kinematics across different stepping speeds and loading conditions. We suggest that the components are related to control signals output by spinal pattern generators, normally under the influence of descending and afferent inputs.

Original languageEnglish
Pages (from-to)3555-3565
Number of pages11
JournalJournal of Neurophysiology
Volume90
Issue number5
DOIs
Publication statusPublished - Nov 2003

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Biomechanical Phenomena
Foot
Spinal Cord
Muscles
Spinal Injuries
Locomotion
Healthy Volunteers
Body Weight
Control Groups

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Temporal Components of the Motor Patterns Expressed by the Human Spinal Cord Reflect Foot Kinematics. / Ivanenko, Yuri P.; Grasso, Renato; Zago, Myrka; Molinari, Marco; Scivoletto, Giorgio; Castellano, Vincenzo; Macellari, Velio; Lacquaniti, Francesco.

In: Journal of Neurophysiology, Vol. 90, No. 5, 11.2003, p. 3555-3565.

Research output: Contribution to journalArticle

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