Temporal gene expression profile of the hippocampus following trace fear conditioning

Alessandra Sirri, Veronica Bianchi, Mattia Pelizzola, Manuel Mayhaus, Paola Ricciardi-Castagnoli, Daniela Toniolo, Patrizia D'Adamo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In this paper we report the results of gene expression profiling of C57Bl/6N mice hippocampus after trace fear conditioning (TFC), and the identification of genes regulated at early and late steps after conditioning. Several of the genes regulated at early steps following TFC appeared common to many training protocols. At later stages (2 and 6 h), most of the genes identified were different from those identified following other learning paradigms resulting in memory consolidation. At 6 h after training, few genes were upregulated in respect to the naïve condition, suggesting that many gene products have eventually to be downregulated to achieve stable synapses modification and memory formation. In conclusion, the results presented highlight a number of genes whose expression is specifically modified in the mouse hippocampus following TFC and demonstrate the specificity associated to different forms of conditioning. Crown

Original languageEnglish
Pages (from-to)14-23
Number of pages10
JournalBrain Research
Volume1308
DOIs
Publication statusPublished - Jan 13 2010

Fingerprint

Transcriptome
Fear
Hippocampus
Genes
Gene Expression Profiling
Crowns
Synapses
Down-Regulation
Conditioning (Psychology)
Learning
Gene Expression

Keywords

  • Gene expression
  • Hippocampus
  • Long-term memory
  • Oligonucleotide microarray
  • Trace fear conditioning

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Sirri, A., Bianchi, V., Pelizzola, M., Mayhaus, M., Ricciardi-Castagnoli, P., Toniolo, D., & D'Adamo, P. (2010). Temporal gene expression profile of the hippocampus following trace fear conditioning. Brain Research, 1308, 14-23. https://doi.org/10.1016/j.brainres.2009.10.049

Temporal gene expression profile of the hippocampus following trace fear conditioning. / Sirri, Alessandra; Bianchi, Veronica; Pelizzola, Mattia; Mayhaus, Manuel; Ricciardi-Castagnoli, Paola; Toniolo, Daniela; D'Adamo, Patrizia.

In: Brain Research, Vol. 1308, 13.01.2010, p. 14-23.

Research output: Contribution to journalArticle

Sirri, A, Bianchi, V, Pelizzola, M, Mayhaus, M, Ricciardi-Castagnoli, P, Toniolo, D & D'Adamo, P 2010, 'Temporal gene expression profile of the hippocampus following trace fear conditioning', Brain Research, vol. 1308, pp. 14-23. https://doi.org/10.1016/j.brainres.2009.10.049
Sirri A, Bianchi V, Pelizzola M, Mayhaus M, Ricciardi-Castagnoli P, Toniolo D et al. Temporal gene expression profile of the hippocampus following trace fear conditioning. Brain Research. 2010 Jan 13;1308:14-23. https://doi.org/10.1016/j.brainres.2009.10.049
Sirri, Alessandra ; Bianchi, Veronica ; Pelizzola, Mattia ; Mayhaus, Manuel ; Ricciardi-Castagnoli, Paola ; Toniolo, Daniela ; D'Adamo, Patrizia. / Temporal gene expression profile of the hippocampus following trace fear conditioning. In: Brain Research. 2010 ; Vol. 1308. pp. 14-23.
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