Temporal lobe connects regression and macrocephaly to autism spectrum disorders

Giulia Valvo, Sara Baldini, Alessandra Retico, Giuseppe Rossi, Raffaella Tancredi, Anna Rita Ferrari, Sara Calderoni, Fabio Apicella, Filippo Muratori, Filippo Maria Santorelli, Federico Sicca

Research output: Contribution to journalArticle

Abstract

Interictal electroencephalogram (EEG) abnormalities are frequently associated with autism spectrum disorders (ASD), although their relationship with the clinical features of ASD, particularly the regressive onset, remains controversial. The aim of this study was to investigate whether the characteristics of interictal EEG abnormalities might help to distinguish and predict definite phenotypes within the heterogeneity of ASD. We reviewed the awake and sleep interictal EEGs of 220 individuals with idiopathic ASD, either with or without a history of seizures. EEG findings were analyzed with respect to a set of clinical variables to explore significant associations. A brain morphometry study was also carried out on a subgroup of patients. EEG abnormalities were seen in 154/220 individuals (70 %) and were mostly focal (p <0.01) with an anterior localization (p <0.001). They were detected more frequently during sleep (p <0.01), and were associated with a regressive onset of ASD (p <0.05), particularly in individuals with focal temporal localization (p <0.05). This association was also stronger in regressive patients with concurrent macrocephaly, together with a relative volumetric reduction of the right temporal cortex (p <0.05). Indeed, concurrence of temporal EEG abnormalities, regression and macrocephaly might possibly define a distinct endophenotype of ASD. EEG-based endophenotypes could be useful to untangle the complexity of ASD, helping to establish anatomic or pathophysiologic subtypes of the disorder.

Original languageEnglish
JournalEuropean Child and Adolescent Psychiatry
DOIs
Publication statusAccepted/In press - Jul 30 2015

Fingerprint

Megalencephaly
Temporal Lobe
Electroencephalography
Endophenotypes
Sleep
Autism Spectrum Disorder
Autism Spectrum Disorders
Electroencephalogram
Seizures
Phenotype
Brain

Keywords

  • Autism
  • EEG
  • Macrocephaly
  • Regression
  • Temporal lobe

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pediatrics, Perinatology, and Child Health
  • Philosophy
  • Developmental and Educational Psychology

Cite this

Temporal lobe connects regression and macrocephaly to autism spectrum disorders. / Valvo, Giulia; Baldini, Sara; Retico, Alessandra; Rossi, Giuseppe; Tancredi, Raffaella; Ferrari, Anna Rita; Calderoni, Sara; Apicella, Fabio; Muratori, Filippo; Santorelli, Filippo Maria; Sicca, Federico.

In: European Child and Adolescent Psychiatry, 30.07.2015.

Research output: Contribution to journalArticle

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