Temporal lobe epilepsy and emotion recognition without amygdala: A case study of Urbach-Wiethe disease and review of the literature

Stefano Meletti, Gaetano Cantalupo, Francesca Santoro, Francesca Benuzzi, Anna Federica Marliani, Carlo Alberto Tassinari, Guido Rubboli

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We describe the epilepsy features and emotion recognition abilities (recognition of basic facial emotions and recognition of emotional prosody) in a patient with Urbach-Wiethe disease with bilateral amygdala calcifications. Our data, supported by ictal video-EEG recording, indicated that our patient suffered from mesial temporal lobe epilepsy. Emotion recognition abilities were compared to those of healthy controls and those of patients with bilateral mesial temporal lobe epilepsy. Our patient showed a selective impairment of the recognition of facial expression of fear, whereas recognition of emotional prosody was preserved, in contrast to bilateral mesial temporal lobe epilepsy patients that presented with deficits in both domains. We also reviewed the literature on epilepsy in Urbach-Wiethe disease (41 patients). Our findings suggest that in Urbach-Wiethe disease, the circumscribed damage of both amygdalae results in a selective dysfunction of fearful face processing, in contrast to bilateral mesial temporal lobe epilepsy patients who present with a widespread and multimodal impairment in the judgement of emotional stimuli.

Original languageEnglish
Pages (from-to)518-527
Number of pages10
JournalEpileptic Disorders
Volume16
Issue number4
DOIs
Publication statusPublished - Dec 1 2014

Fingerprint

Lipoid Proteinosis of Urbach and Wiethe
Temporal Lobe Epilepsy
Amygdala
Emotions
Aptitude
Epilepsy
Video Recording
Facial Expression
Recognition (Psychology)
Fear
Electroencephalography
Stroke

Keywords

  • Amygdala
  • Emotion recognition
  • Emotional prosody
  • Lipoid proteinosis
  • Temporal lobe epilepsy
  • Urbach-Wiethe disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Temporal lobe epilepsy and emotion recognition without amygdala : A case study of Urbach-Wiethe disease and review of the literature. / Meletti, Stefano; Cantalupo, Gaetano; Santoro, Francesca; Benuzzi, Francesca; Marliani, Anna Federica; Tassinari, Carlo Alberto; Rubboli, Guido.

In: Epileptic Disorders, Vol. 16, No. 4, 01.12.2014, p. 518-527.

Research output: Contribution to journalArticle

Meletti, Stefano ; Cantalupo, Gaetano ; Santoro, Francesca ; Benuzzi, Francesca ; Marliani, Anna Federica ; Tassinari, Carlo Alberto ; Rubboli, Guido. / Temporal lobe epilepsy and emotion recognition without amygdala : A case study of Urbach-Wiethe disease and review of the literature. In: Epileptic Disorders. 2014 ; Vol. 16, No. 4. pp. 518-527.
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