Temporal lobe epilepsy: Correlation of proton magnetic resonance spectroscopy and 18F-fluorodeoxyglucose positron emission tomography

Dongfeng Lu, Claude Margouleff, Eric Rubin, Douglas Labar, Neil Schaul, Tatsuya Ishikawa, Ken Kazumata, Angelo Antonini, Vijay Dhawan, Roger A. Hyman, David Eidelberg

Research output: Contribution to journalArticle

Abstract

Proton magnetic resonance spectroscopy (MRS) has demonstrated reduction of N-acetylaspartate (NAA) in the epileptogenic temporal lobe. However, the correlation of NAA reduction with cerebral metabolic abnormalities is unknown in temporal lobe epilepsy (TLE). Proton MRS and 18F-fluorodeoxyglucose positron emission tomography (FDG/PET) were used to study 12 unilateral TLE patients with medically intractable seizures and 26 age-matched healthy volunteers. The epileptogenic temporal lobe of each patient was determined by both electroencephalography and FDG/PET. The NAA/choline-plus-creatine (NAA/(Cho+Cr)) ratio correlated significantly with the interictal glucose metabolism (r = 0.54, P <0.01) in 12 TLE patients. The mean NAA/(Cho+Cr) ratio in the epileptogenic temporal lobe was significantly less than that in the contralateral side (P <0.01), and less than that in normal control temporal lobes (P <0.0001). These results suggest that quantitative MRS abnormalities reflect underlying metabolic pathology in TLE.

Original languageEnglish
Pages (from-to)18-23
Number of pages6
JournalMagnetic Resonance in Medicine
Volume37
Issue number1
DOIs
Publication statusPublished - Jan 1997

Keywords

  • F-fluorodeoxyglucose positron emission tomography
  • brain
  • MR spectroscopy
  • temporal lobe epilepsy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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    Lu, D., Margouleff, C., Rubin, E., Labar, D., Schaul, N., Ishikawa, T., Kazumata, K., Antonini, A., Dhawan, V., Hyman, R. A., & Eidelberg, D. (1997). Temporal lobe epilepsy: Correlation of proton magnetic resonance spectroscopy and 18F-fluorodeoxyglucose positron emission tomography. Magnetic Resonance in Medicine, 37(1), 18-23. https://doi.org/10.1002/mrm.1910370105