TY - JOUR
T1 - Temporal lobe epilepsy
T2 - Correlation of proton magnetic resonance spectroscopy and 18F-fluorodeoxyglucose positron emission tomography
AU - Lu, Dongfeng
AU - Margouleff, Claude
AU - Rubin, Eric
AU - Labar, Douglas
AU - Schaul, Neil
AU - Ishikawa, Tatsuya
AU - Kazumata, Ken
AU - Antonini, Angelo
AU - Dhawan, Vijay
AU - Hyman, Roger A.
AU - Eidelberg, David
PY - 1997/1
Y1 - 1997/1
N2 - Proton magnetic resonance spectroscopy (MRS) has demonstrated reduction of N-acetylaspartate (NAA) in the epileptogenic temporal lobe. However, the correlation of NAA reduction with cerebral metabolic abnormalities is unknown in temporal lobe epilepsy (TLE). Proton MRS and 18F-fluorodeoxyglucose positron emission tomography (FDG/PET) were used to study 12 unilateral TLE patients with medically intractable seizures and 26 age-matched healthy volunteers. The epileptogenic temporal lobe of each patient was determined by both electroencephalography and FDG/PET. The NAA/choline-plus-creatine (NAA/(Cho+Cr)) ratio correlated significantly with the interictal glucose metabolism (r = 0.54, P <0.01) in 12 TLE patients. The mean NAA/(Cho+Cr) ratio in the epileptogenic temporal lobe was significantly less than that in the contralateral side (P <0.01), and less than that in normal control temporal lobes (P <0.0001). These results suggest that quantitative MRS abnormalities reflect underlying metabolic pathology in TLE.
AB - Proton magnetic resonance spectroscopy (MRS) has demonstrated reduction of N-acetylaspartate (NAA) in the epileptogenic temporal lobe. However, the correlation of NAA reduction with cerebral metabolic abnormalities is unknown in temporal lobe epilepsy (TLE). Proton MRS and 18F-fluorodeoxyglucose positron emission tomography (FDG/PET) were used to study 12 unilateral TLE patients with medically intractable seizures and 26 age-matched healthy volunteers. The epileptogenic temporal lobe of each patient was determined by both electroencephalography and FDG/PET. The NAA/choline-plus-creatine (NAA/(Cho+Cr)) ratio correlated significantly with the interictal glucose metabolism (r = 0.54, P <0.01) in 12 TLE patients. The mean NAA/(Cho+Cr) ratio in the epileptogenic temporal lobe was significantly less than that in the contralateral side (P <0.01), and less than that in normal control temporal lobes (P <0.0001). These results suggest that quantitative MRS abnormalities reflect underlying metabolic pathology in TLE.
KW - F-fluorodeoxyglucose positron emission tomography
KW - brain
KW - MR spectroscopy
KW - temporal lobe epilepsy
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U2 - 10.1002/mrm.1910370105
DO - 10.1002/mrm.1910370105
M3 - Article
C2 - 8978628
AN - SCOPUS:8044220284
VL - 37
SP - 18
EP - 23
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
SN - 0740-3194
IS - 1
ER -