Temporal processing of visuotactile and tactile stimuli in writer's cramp

Mirta Fiorio, Michele Tinazzi, Laura Bertolasi, Salvatore M. Aglioti

Research output: Contribution to journalArticlepeer-review

Abstract

Neurophysiological studies in animals show that basal ganglia are involved not only in motor and nonmotor timing functions but also in integrating tactile and visual signals delivered in the peripersonal space. We tested temporal discrimination of cross-modal and unimodal stimuli in 13 controls and 14 patients with writer's cramp, a disorder supposedly linked to dysfunction of basal ganglia. Subjects were asked to discriminate whether pairs of visual, tactile, or visuotactile stimuli were simultaneous or sequential (temporal discrimination threshold) and which stimulus preceded the other (temporal order judgment). Patients were impaired in temporal processing of tactile and cross-modal stimuli. A significant positive correlation between temporal deficits and the severity of disability was detected for both affected and unaffected sides. Findings suggest that multimodal and not only modality-specific temporal processing is defective in focal hand dystonia. Deficits of temporal processing of stimuli delivered to the unaffected side may represent a behavioral index of the susceptibility to develop dystonia and thus have remarkable practical and theoretical implications.

Original languageEnglish
Pages (from-to)630-635
Number of pages6
JournalAnnals of Neurology
Volume53
Issue number5
DOIs
Publication statusPublished - May 1 2003

ASJC Scopus subject areas

  • Neuroscience(all)

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