TY - JOUR
T1 - Temporal relationship between bone loss and increased bone turnover
T2 - A longitudinal study following natural menopause
AU - Rosso, R.
AU - Minisola, S.
AU - Scarda, A.
AU - Pacitti, M. T.
AU - Carnevale, V.
AU - Romagnoli, E.
AU - Mazzuoli, G. F.
PY - 1995
Y1 - 1995
N2 - We report the results of a longitudinal study aimed at better defining concomitant changes of both bone mineral density (BMD) and of four independent markers of bone turnover (serum osteocalcin, serum alkaline phosphatase activity, fasting urinary hydroxyproline/creatinine and calcium/creatinine ratio) following natural menopause. The results obtained indicate that, within a relatively short period of time since cessation of gonadal function, conventional markers of bone turnover behave differently. In fact, while the mean values of hydroxyproline/creatinine ratio ( felt to be a marker of bone résorption) rise immediately at the first control (19.7±11.7 months), the bone formation markers gradually increase and, as far as serum osteocalcin levels are concerned, this increment appears to be long-lasting. As a result of these changes, a negative skeletal balance follows, which is documented by the prolonged reduction of bone mineral density during the entire observation period. Mean±SD % measured yearly bone loss was −2.83±2.6. There was a highly significant correlation between initial and final BMD values (r= 0.908, p2= 82.5) and a weak inverse correlation (r = −0.298, p
AB - We report the results of a longitudinal study aimed at better defining concomitant changes of both bone mineral density (BMD) and of four independent markers of bone turnover (serum osteocalcin, serum alkaline phosphatase activity, fasting urinary hydroxyproline/creatinine and calcium/creatinine ratio) following natural menopause. The results obtained indicate that, within a relatively short period of time since cessation of gonadal function, conventional markers of bone turnover behave differently. In fact, while the mean values of hydroxyproline/creatinine ratio ( felt to be a marker of bone résorption) rise immediately at the first control (19.7±11.7 months), the bone formation markers gradually increase and, as far as serum osteocalcin levels are concerned, this increment appears to be long-lasting. As a result of these changes, a negative skeletal balance follows, which is documented by the prolonged reduction of bone mineral density during the entire observation period. Mean±SD % measured yearly bone loss was −2.83±2.6. There was a highly significant correlation between initial and final BMD values (r= 0.908, p2= 82.5) and a weak inverse correlation (r = −0.298, p
KW - biomarkers
KW - bone mineral density
KW - bone turnover
KW - Menopause
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U2 - 10.1007/BF03349795
DO - 10.1007/BF03349795
M3 - Article
C2 - 8719304
AN - SCOPUS:0029609888
VL - 18
SP - 723
EP - 728
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
SN - 0391-4097
IS - 9
ER -