Temporal relationship of generalized epileptiform discharges to spindle frequency activity in childhood absence epilepsy

Lino Nobili, Maria Giuseppina Baglietto, Manolo Beelke, Fabrizio De Carli, Edvige Veneselli, Franco Ferrillo

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The hypothesis that the two main synchronizing mechanisms (spindle and delta oscillations) acting during non-rapid eye movement sleep show opposite relationship with the distribution of generalized epileptiform discharges (GEDs) during sleep was evaluated. Methods: We studied the temporal relationship between the distribution of sleep GEDs and the dynamics of Sigma Activity (SA, 12-16 Hz) and Delta Activity (DA, 0.5-4.5 Hz) in 5 children affected by childhood absence epilepsy. Results: Using correlation techniques, we found a high and positive correlation between GEDs and SA, while DA resulted negatively correlated with GEDs. Conclusion: Sleep generalized spike-and-slow-waves seems to be produced when spindle synchronizing mechanisms are active while DA production seem to exert an inhibiting role. Such a feature seems to be common to other childhood partial and undetermined epileptic syndromes.

Original languageEnglish
Pages (from-to)1912-1916
Number of pages5
JournalClinical Neurophysiology
Volume112
Issue number10
DOIs
Publication statusPublished - 2001

Keywords

  • Delta activity
  • Epilepsy
  • Sigma activity
  • Sleep
  • Spindles

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems

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