Temporal trends and social barriers for inpatient palliative care delivery in metastatic prostate cancer patients receiving critical care therapies: Prostate Cancer and Prostatic Diseases

E. Mazzone, F.A. Mistretta, S. Knipper, Z. Tian, C. Palumbo, G. Gandaglia, N. Fossati, S.F. Shariat, F. Saad, F. Montorsi, M. Graefen, A. Briganti, P.I. Karakiewicz

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Use of inpatient palliative care (IPC) in advanced cancer patients represents a well-established guideline recommendation. A recent analysis demonstrated that genitourinary (GU) cancer patients benefited of IPC at the second lowest rate within the four examined primaries, namely lung, breast, colorectal, and GU. Based on this observation, we examined temporal trends and predictors of IPC use in metastatic prostate cancer patients receiving critical care therapies (CCT). Materials and methods: We identified mPCa patients receiving CCT within the Nationwide Inpatient Sample database (2004–2015). IPC use rates were evaluated using univariable estimated annual percentage changes analyses. Multivariable logistic regression (MLR) models were used after adjustment for clustering at hospital level. Results: Of 4168 mPCa patients receiving CCT, 449 (11.3%) received IPC. IPC use increased from 1.2 to 22.3% (EAPC: +19.6%, p < 0.001). After stratification according to regions, race, and teaching status, the highest increase of IPC use was recorded in the South (from 0 to 25.4 %, EAPC: +27.6%), in Caucasians (from 1.5 to 24.4 %, EAPC: +19.8%; p < 0.001) and in teaching hospitals (from 0.9 to 26.2 %, EAPC: +19.6%; p < 0.001). In MLR models, teaching status (Odds ratio [OR]: 1.74, p < 0.001) and contemporary year interval (OR: 4.63, p < 0.001) were associated with higher IPC rates. Conversely, African American race (OR: 0.66, p < 0.001) and primary diagnosis of GU disorders (OR: 0.49, p < 0.001) and gastrointestinal (GI) disorders at admission (OR: 0.61, p = 0.02) were associated with lower IPC rates. Conclusions: IPC use rate in mPCa patients receiving CCT sharply increased between 2004 and 2015. The highest increase of IPC use across time was recorded in the South, in Caucasian race, and in teaching hospitals. African-American race and nonteaching status were identified as independent predictors of lower IPC use and represent targets for efforts aimed at improving IPC delivery in mPCa patients receiving CCT. © 2019, The Author(s), under exclusive licence to Springer Nature Limited.
Original languageEnglish
Pages (from-to)260-268
Number of pages9
JournalProstate Cancer Prostatic Dis.
Volume23
Issue number2
DOIs
Publication statusPublished - 2020

Keywords

  • African American
  • aged
  • Article
  • artificial ventilation
  • Caucasian
  • gastrointestinal disease
  • health care delivery
  • hospital admission
  • hospital patient
  • human
  • intensive care
  • major clinical study
  • male
  • metastasis
  • palliative therapy
  • parenteral nutrition
  • percutaneous endoscopic gastrostomy
  • priority journal
  • prostate cancer
  • teaching hospital
  • trend study
  • urogenital tract disease

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