Temporal variation in soluble human leukocyte antigen-G (sHLA-G) and pregnancy-associated plasma protein A (PAPP-A) in pregnancies complicated by gestational diabetes mellitus and in controls

Fausta Beneventi, Margherita Simonetta, Elena Locatelli, Chiara Cavagnoli, Carla Badulli, Elisabetta Lovati, Giulia Garbin, Emilia Genini, Riccardo Albertini, Carmine Tinelli, Miryam Martinetti, Arsenio Spinillo

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19 Citations (Scopus)

Abstract

Problem: To target gestational diabetes mellitus (GDM) by means of temporal variation in pregnancy-associated plasma protein A (PAPP-A) and soluble human leukocyte antigen-G (sHLA-G). Method of study: Retrospective analysis of PAPP-A and sHLA-G blood levels in historical samples of 112 GDM and 112 controls, drawn at first trimester, and prospective study in 18 GDM and 105 controls collected in triplicate along the pregnancy. Six hundred and sixty-five samples were analyzed. Results: Gestational diabetes mellitus had significantly lower first-trimester PAPP-A concentrations than controls (2343 ± 1519 versus 2996 ± 1955 mU/mL, in retrospective brunch and 2490.57 ± 1828.52 versus 3240.84 ± 1930.69 mU/L in prospective one, P <0.001). First-trimester sHLA-G level was significantly lower in GDM than in controls (52.88 ± 59.69 versus 66.81 ± 50.14 ng/mL, P <0.001) and increased during gestation in diabetic women showing an opposite trend with respect to the controls. Conclusion: PAPP-A and sHLA-G are independent markers of GDM. Quantitative variations during pregnancy help to early unravel the onset of GDM.

Original languageEnglish
Pages (from-to)413-421
Number of pages9
JournalAmerican Journal of Reproductive Immunology
Volume72
Issue number4
DOIs
Publication statusPublished - 2014

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Pregnancy-Associated Plasma Protein-A
Gestational Diabetes
HLA Antigens
Pregnancy
First Pregnancy Trimester
Retrospective Studies
Prospective Studies

Keywords

  • Altered glucose metabolism
  • Human pregnancy
  • Predictive biomarkers

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Medicine(all)

Cite this

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title = "Temporal variation in soluble human leukocyte antigen-G (sHLA-G) and pregnancy-associated plasma protein A (PAPP-A) in pregnancies complicated by gestational diabetes mellitus and in controls",
abstract = "Problem: To target gestational diabetes mellitus (GDM) by means of temporal variation in pregnancy-associated plasma protein A (PAPP-A) and soluble human leukocyte antigen-G (sHLA-G). Method of study: Retrospective analysis of PAPP-A and sHLA-G blood levels in historical samples of 112 GDM and 112 controls, drawn at first trimester, and prospective study in 18 GDM and 105 controls collected in triplicate along the pregnancy. Six hundred and sixty-five samples were analyzed. Results: Gestational diabetes mellitus had significantly lower first-trimester PAPP-A concentrations than controls (2343 ± 1519 versus 2996 ± 1955 mU/mL, in retrospective brunch and 2490.57 ± 1828.52 versus 3240.84 ± 1930.69 mU/L in prospective one, P <0.001). First-trimester sHLA-G level was significantly lower in GDM than in controls (52.88 ± 59.69 versus 66.81 ± 50.14 ng/mL, P <0.001) and increased during gestation in diabetic women showing an opposite trend with respect to the controls. Conclusion: PAPP-A and sHLA-G are independent markers of GDM. Quantitative variations during pregnancy help to early unravel the onset of GDM.",
keywords = "Altered glucose metabolism, Human pregnancy, Predictive biomarkers",
author = "Fausta Beneventi and Margherita Simonetta and Elena Locatelli and Chiara Cavagnoli and Carla Badulli and Elisabetta Lovati and Giulia Garbin and Emilia Genini and Riccardo Albertini and Carmine Tinelli and Miryam Martinetti and Arsenio Spinillo",
year = "2014",
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language = "English",
volume = "72",
pages = "413--421",
journal = "American Journal of Reproductive Immunology and Microbiology",
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T1 - Temporal variation in soluble human leukocyte antigen-G (sHLA-G) and pregnancy-associated plasma protein A (PAPP-A) in pregnancies complicated by gestational diabetes mellitus and in controls

AU - Beneventi, Fausta

AU - Simonetta, Margherita

AU - Locatelli, Elena

AU - Cavagnoli, Chiara

AU - Badulli, Carla

AU - Lovati, Elisabetta

AU - Garbin, Giulia

AU - Genini, Emilia

AU - Albertini, Riccardo

AU - Tinelli, Carmine

AU - Martinetti, Miryam

AU - Spinillo, Arsenio

PY - 2014

Y1 - 2014

N2 - Problem: To target gestational diabetes mellitus (GDM) by means of temporal variation in pregnancy-associated plasma protein A (PAPP-A) and soluble human leukocyte antigen-G (sHLA-G). Method of study: Retrospective analysis of PAPP-A and sHLA-G blood levels in historical samples of 112 GDM and 112 controls, drawn at first trimester, and prospective study in 18 GDM and 105 controls collected in triplicate along the pregnancy. Six hundred and sixty-five samples were analyzed. Results: Gestational diabetes mellitus had significantly lower first-trimester PAPP-A concentrations than controls (2343 ± 1519 versus 2996 ± 1955 mU/mL, in retrospective brunch and 2490.57 ± 1828.52 versus 3240.84 ± 1930.69 mU/L in prospective one, P <0.001). First-trimester sHLA-G level was significantly lower in GDM than in controls (52.88 ± 59.69 versus 66.81 ± 50.14 ng/mL, P <0.001) and increased during gestation in diabetic women showing an opposite trend with respect to the controls. Conclusion: PAPP-A and sHLA-G are independent markers of GDM. Quantitative variations during pregnancy help to early unravel the onset of GDM.

AB - Problem: To target gestational diabetes mellitus (GDM) by means of temporal variation in pregnancy-associated plasma protein A (PAPP-A) and soluble human leukocyte antigen-G (sHLA-G). Method of study: Retrospective analysis of PAPP-A and sHLA-G blood levels in historical samples of 112 GDM and 112 controls, drawn at first trimester, and prospective study in 18 GDM and 105 controls collected in triplicate along the pregnancy. Six hundred and sixty-five samples were analyzed. Results: Gestational diabetes mellitus had significantly lower first-trimester PAPP-A concentrations than controls (2343 ± 1519 versus 2996 ± 1955 mU/mL, in retrospective brunch and 2490.57 ± 1828.52 versus 3240.84 ± 1930.69 mU/L in prospective one, P <0.001). First-trimester sHLA-G level was significantly lower in GDM than in controls (52.88 ± 59.69 versus 66.81 ± 50.14 ng/mL, P <0.001) and increased during gestation in diabetic women showing an opposite trend with respect to the controls. Conclusion: PAPP-A and sHLA-G are independent markers of GDM. Quantitative variations during pregnancy help to early unravel the onset of GDM.

KW - Altered glucose metabolism

KW - Human pregnancy

KW - Predictive biomarkers

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