TY - JOUR
T1 - Temporary intraocular pressure lowering by photodynamic therapy in pseudoexfoliation glaucoma
AU - Parodi, Maurizio Battaglia
AU - Iacono, Pierluigi
AU - Bandello, Francesco
PY - 2011/1
Y1 - 2011/1
N2 - ■ BACKGROUND AND OBJECTIVE: The aim of the study was to ascertain whether photodynamic therapy (PDT) with verteporfin is able to reduce the blood - aqueous barrier impairment in eyes affected by pseudoexfoliative glaucoma (PESG) with consequent intraocular pressure (IOP) lowering. ■ PATIENTS AND METHODS: Five patients with poorly controlled PESG were selected. The laser energy was directed to the anterior chamber angle and the iris surface by means of a Goldmann lens. ■ RESULTS: IOP reduction was registered 1 month after PDT and lasted 3 months, reaching the values registered before PDT after that. Iris fluorescein angiography 1 week and 1 month after PDT showed reduced dye leakage, but the same amount of dye leakage visible before PDT was detectable 3 months later. ■ CONCLUSION: PDT can reduce the breakdown of the blood - aqueous barrier and can lower the IOP temporarily in eyes affected by PESG. Further studies are needed to analyze the biochemical changes after PDT in aqueous humor.
AB - ■ BACKGROUND AND OBJECTIVE: The aim of the study was to ascertain whether photodynamic therapy (PDT) with verteporfin is able to reduce the blood - aqueous barrier impairment in eyes affected by pseudoexfoliative glaucoma (PESG) with consequent intraocular pressure (IOP) lowering. ■ PATIENTS AND METHODS: Five patients with poorly controlled PESG were selected. The laser energy was directed to the anterior chamber angle and the iris surface by means of a Goldmann lens. ■ RESULTS: IOP reduction was registered 1 month after PDT and lasted 3 months, reaching the values registered before PDT after that. Iris fluorescein angiography 1 week and 1 month after PDT showed reduced dye leakage, but the same amount of dye leakage visible before PDT was detectable 3 months later. ■ CONCLUSION: PDT can reduce the breakdown of the blood - aqueous barrier and can lower the IOP temporarily in eyes affected by PESG. Further studies are needed to analyze the biochemical changes after PDT in aqueous humor.
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U2 - 10.3928/15428877-20101124-05
DO - 10.3928/15428877-20101124-05
M3 - Article
C2 - 21117580
AN - SCOPUS:79954438398
VL - 42
SP - 53
EP - 58
JO - Ophthalmic Surgery Lasers and Imaging
JF - Ophthalmic Surgery Lasers and Imaging
SN - 1542-8877
IS - 1
ER -