Temporin A soaking in combination with intraperitoneal linezolid prevents vascular graft infection in a subcutaneous rat pouch model of infection with Staphylococcus epidermidis with intermediate resistance to glycopeptides

Andrea Giacometti, Oscar Cirioni, Roberto Ghiselli, Fiorenza Orlando, Giuseppina D'Amato, Wojciech Kamysz, Federico Mocchegiani, Valerio Sisti, Carmela Silvestri, Jerzy Łukasiak, Marco Rocchi, Vittorio Saba, Giorgio Scalise

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The efficacy of linezolid and temporin A in the prevention of prosthetic graft infection due to methicillin-resistant Staphylococcus epidermidis with intermediate resistance to glycopeptides was investigated in a subcutaneous rat pouch model. Linezolid and temporin A, alone or combined, greatly reduced the bacterial numbers compared to the effect with control drugs.

Original languageEnglish
Pages (from-to)3162-3164
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume48
Issue number8
DOIs
Publication statusPublished - Aug 2004

Fingerprint

Linezolid
Staphylococcus epidermidis
Glycopeptides
Blood Vessels
Transplants
Methicillin Resistance
Drug and Narcotic Control
Infection
temporin

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Temporin A soaking in combination with intraperitoneal linezolid prevents vascular graft infection in a subcutaneous rat pouch model of infection with Staphylococcus epidermidis with intermediate resistance to glycopeptides. / Giacometti, Andrea; Cirioni, Oscar; Ghiselli, Roberto; Orlando, Fiorenza; D'Amato, Giuseppina; Kamysz, Wojciech; Mocchegiani, Federico; Sisti, Valerio; Silvestri, Carmela; Łukasiak, Jerzy; Rocchi, Marco; Saba, Vittorio; Scalise, Giorgio.

In: Antimicrobial Agents and Chemotherapy, Vol. 48, No. 8, 08.2004, p. 3162-3164.

Research output: Contribution to journalArticle

Giacometti, Andrea ; Cirioni, Oscar ; Ghiselli, Roberto ; Orlando, Fiorenza ; D'Amato, Giuseppina ; Kamysz, Wojciech ; Mocchegiani, Federico ; Sisti, Valerio ; Silvestri, Carmela ; Łukasiak, Jerzy ; Rocchi, Marco ; Saba, Vittorio ; Scalise, Giorgio. / Temporin A soaking in combination with intraperitoneal linezolid prevents vascular graft infection in a subcutaneous rat pouch model of infection with Staphylococcus epidermidis with intermediate resistance to glycopeptides. In: Antimicrobial Agents and Chemotherapy. 2004 ; Vol. 48, No. 8. pp. 3162-3164.
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