Ten and eight-day sequential therapy in comparison to standard triple therapy for eradicating helicobacter pylori infection: A randomized controlled study on efficacy and tolerability

Omero Alessandro Paoluzi, Emanuela Visconti, Fabio Andrei, Claudio Tosti, Raffaella Lionetti, Enrico Grasso, Riccardo Ranaldi, Italo Stroppa, Francesco Pallone

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background: Sequential therapy (SQT) is effective in the eradication of Helicobacter pylori and could become an alternative to standard triple therapy (STT). AIM: To compare the efficacy and tolerability of SQT, for either 8 or 10 days, with a 7-day STT. Methods: A total of 270 naive H. pylori-positive patients were randomized to receive: SQT for 8 days (SQT-8, n=90) or 10 days (SQT-10, n=90) including esomeprazole 20mg twice daily (bid) associated with amoxicillin 1000mg bid (early 4 and 5d, respectively), followed by esomeprazole 20mg bid associated with clarithromycin 500mg bid plus tinidazole 500mg bid (last 4 and 5d, respectively); STT (n=90) including esomeprazole 20mg bid plus amoxicillin 1000mg bid and clarithromycin 500mg bid for 7 days. Tolerability was assessed by scoring the severity of symptoms. Results: Eradication rates after SQT-8 and SQT-10 were higher than that of after STT at both intention-to-treat (83% and 86% vs. 66%, P

Original languageEnglish
Pages (from-to)261-266
Number of pages6
JournalJournal of Clinical Gastroenterology
Volume44
Issue number4
DOIs
Publication statusPublished - Apr 2010

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Helicobacter Infections
Helicobacter pylori
Esomeprazole
Therapeutics
Clarithromycin
Amoxicillin
Tinidazole

Keywords

  • Helicobacter pylori
  • Sequential eradication therapy
  • Standard triple therapy
  • Urea breath test

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Ten and eight-day sequential therapy in comparison to standard triple therapy for eradicating helicobacter pylori infection : A randomized controlled study on efficacy and tolerability. / Paoluzi, Omero Alessandro; Visconti, Emanuela; Andrei, Fabio; Tosti, Claudio; Lionetti, Raffaella; Grasso, Enrico; Ranaldi, Riccardo; Stroppa, Italo; Pallone, Francesco.

In: Journal of Clinical Gastroenterology, Vol. 44, No. 4, 04.2010, p. 261-266.

Research output: Contribution to journalArticle

Paoluzi, Omero Alessandro ; Visconti, Emanuela ; Andrei, Fabio ; Tosti, Claudio ; Lionetti, Raffaella ; Grasso, Enrico ; Ranaldi, Riccardo ; Stroppa, Italo ; Pallone, Francesco. / Ten and eight-day sequential therapy in comparison to standard triple therapy for eradicating helicobacter pylori infection : A randomized controlled study on efficacy and tolerability. In: Journal of Clinical Gastroenterology. 2010 ; Vol. 44, No. 4. pp. 261-266.
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AU - Lionetti, Raffaella

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