Ten daily fractions for partial breast irradiation. Long-term results of a prospective phase II trial

Lorenzo Vinante, Michele Avanzo, Carlo Furlan, Francesco Fiorica, Tiziana Perin, Loredana Militello, Simon Spazzapan, Massimiliano Berretta, Rajesh Jena, Joseph Stancanello, Erica Piccoli, Mario Mileto, Elvia Micheli, Mario Roncadin, Samuele Massarut, Marco Trovò

Research output: Contribution to journalArticle

Abstract

Partial breast irradiation (PBI) is an effective adjuvant treatment after breast conservative surgery for selected early-stage breast cancer patients. However, the best fractionation scheme is not well defined. Hereby, we report the 5-year clinical outcome and toxicity of a phase II prospective study of a novel regimen to deliver PBI, which consists in 40 Gy delivered in 10 daily fractions. Patients with early-stage (pT1-pT2, pN0-pN1a, M0) invasive breast cancer were enrolled after conservative surgery. The minimum age at diagnosis was 60 years old. PBI was delivered with 3D-conformal radiotherapy technique with a total dose of 40 Gy, fractionated in 10 daily fractions (4 Gy/fraction). Eighty patients were enrolled. The median follow-up was 67 months. Five-year local control (LC), disease-free survival (DFS), and overall survival (OS) were 95%, 91%, and 96%, respectively. Grade I and II subcutaneous fibrosis were documented in 23% and 5% of cases. No grade III late toxicity was observed. PBI delivered in 40 Gy in 10 daily fractions provided good clinical results and was a valid radiotherapy option for early-stage breast cancer patients.

Original languageEnglish
Pages (from-to)243-249
Number of pages7
JournalBreast Journal
Volume25
Issue number2
DOIs
Publication statusPublished - Mar 1 2019

Keywords

  • breast cancer
  • clinical outcome
  • hypofractionation
  • partial breast irradiation
  • toxicity

ASJC Scopus subject areas

  • Internal Medicine
  • Surgery
  • Oncology

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    Vinante, L., Avanzo, M., Furlan, C., Fiorica, F., Perin, T., Militello, L., Spazzapan, S., Berretta, M., Jena, R., Stancanello, J., Piccoli, E., Mileto, M., Micheli, E., Roncadin, M., Massarut, S., & Trovò, M. (2019). Ten daily fractions for partial breast irradiation. Long-term results of a prospective phase II trial. Breast Journal, 25(2), 243-249. https://doi.org/10.1111/tbj.13195