Ten things you need to know about intensive care unit management of mechanically ventilated patients with COVID-19

Chiara Robba, Denise Battaglini, Lorenzo Ball, Paolo Pelosi, Patricia R.M. Rocco

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction: The ongoing pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed important challenges for clinicians and health-care systems worldwide. Areas covered: The aim of this manuscript is to provide brief guidance for intensive care unit management of mechanically ventilated patients with COVID-19 based on the literature and our direct experience with this population. PubMed, EBSCO, and the Cochrane Library were searched up until 15th of January 2021 for relevant literature. Expert opinion: Initially, the respiratory management of COVID-19 relied on the general therapeutic principles for acute respiratory distress syndrome; however, recent findings have suggested that the pathophysiology of hypoxemia in patients with COVID-19 presents specific features and changes over time. Several therapies, including antiviral and anti-inflammatory agents, have been proposed recently. The optimal intensive care unit management of patients with COVID-19 remains unclear; therefore, ongoing and future clinical trials are warranted to clarify the optimal strategies to adopt in this cohort of patients.

Original languageEnglish
JournalExpert Review of Respiratory Medicine
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • antibiotic therapy
  • anticoagulation
  • corticosteroids
  • mechanical ventilation
  • Severe acute respiratory syndrome coronavirus-2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health

Fingerprint

Dive into the research topics of 'Ten things you need to know about intensive care unit management of mechanically ventilated patients with COVID-19'. Together they form a unique fingerprint.

Cite this