Ten-year experience with CMF-based adjuvant chemotherapy in resectable breast cancer

G. Bonadonna, P. Valagussa, A. Rossi, G. Tancini, C. Brambilla, M. Zambetti, U. Veronesi

Research output: Contribution to journalArticle

237 Citations (Scopus)

Abstract

The paper reviews all adjuvant studies carried out since 1973 at the Milan Cancer Institute in women with resectable breast cancer and positive axillary nodes. The updated results essentially confirm previous findings, and indicate that CMF-based chemotherapy is able to exert a prolonged therapeutic activity in a fraction of patients bearing micrometastases. In particular, the first randomized study testing no postoperative chemotherapy vs 12 CMF cycles, showed a 10-year relapse free survival (RFS) of 31.4% vs 43.4% (P

Original languageEnglish
Pages (from-to)95-115
Number of pages21
JournalBreast Cancer Research and Treatment
Volume5
Issue number2
DOIs
Publication statusPublished - Jun 1985

Fingerprint

Adjuvant Chemotherapy
Breast Neoplasms
Drug Therapy
Neoplasm Micrometastasis
Recurrence
Survival
Neoplasms
Therapeutics

Keywords

  • adjuvant treatment
  • breast cancer
  • chemotherapy
  • CMF program

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Bonadonna, G., Valagussa, P., Rossi, A., Tancini, G., Brambilla, C., Zambetti, M., & Veronesi, U. (1985). Ten-year experience with CMF-based adjuvant chemotherapy in resectable breast cancer. Breast Cancer Research and Treatment, 5(2), 95-115. https://doi.org/10.1007/BF01805984

Ten-year experience with CMF-based adjuvant chemotherapy in resectable breast cancer. / Bonadonna, G.; Valagussa, P.; Rossi, A.; Tancini, G.; Brambilla, C.; Zambetti, M.; Veronesi, U.

In: Breast Cancer Research and Treatment, Vol. 5, No. 2, 06.1985, p. 95-115.

Research output: Contribution to journalArticle

Bonadonna, G, Valagussa, P, Rossi, A, Tancini, G, Brambilla, C, Zambetti, M & Veronesi, U 1985, 'Ten-year experience with CMF-based adjuvant chemotherapy in resectable breast cancer', Breast Cancer Research and Treatment, vol. 5, no. 2, pp. 95-115. https://doi.org/10.1007/BF01805984
Bonadonna G, Valagussa P, Rossi A, Tancini G, Brambilla C, Zambetti M et al. Ten-year experience with CMF-based adjuvant chemotherapy in resectable breast cancer. Breast Cancer Research and Treatment. 1985 Jun;5(2):95-115. https://doi.org/10.1007/BF01805984
Bonadonna, G. ; Valagussa, P. ; Rossi, A. ; Tancini, G. ; Brambilla, C. ; Zambetti, M. ; Veronesi, U. / Ten-year experience with CMF-based adjuvant chemotherapy in resectable breast cancer. In: Breast Cancer Research and Treatment. 1985 ; Vol. 5, No. 2. pp. 95-115.
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