OBJECTIVE: To evaluate long-term outcomes after surgery for apparent early-stage ovarian cancer (OC). METHODS: Retrospective analysis of women who underwent staging surgery for apparent early-stage OC at a single center in Milan, Italy, from 1990 to 2008, and had a follow-up longer than 10 years (living women with no recurrence). Univariate and multivariate analyses and propensity score matching were carried out. RESULTS: Overall, 182 women underwent radical (n=148, 81.3 or conservative (n=34, 18.7 procedures for early-stage OC. Ten-year disease-free and overall survival were 82.9n=151) and 87.9n=160), respectively. Conservative or radical surgery had similar disease-free (log-rank test, P=0.783) and overall (log-rank test, P=0.783) survival. These data were confirmed after the application of propensity score matching. High-risk features correlated with non-significant worse disease-free survival (P=0.080). In the high-risk group (≥Grade 3 or ≥ Stage IC), type of surgical approach (conservative vs radical) did not affect survival (hazard ratio, 0.81; 95 0.18-3.56; P=0.781). CONCLUSION: Women with early-stage OC had encouraging long-term survival. The presence of high-risk disease had detrimental effects on survival, regardless of surgical approach. High-risk disease should not be considered a contraindication to conservative surgery.
|Journal||International Journal of Gynecology and Obstetrics|
|Publication status||Published - Aug 1 2020|