Ten-year survival in 290 patients with endometrial cancer: prognostic factors and therapeutic approach

Carlo La Vecchia, Silvia Franceschi, Fabio Parazzini, Elena Colombo, Fabio Colombo, Alessandro Liberati, Costantino Mangioni

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Abstract

Between 1970 and 1976, 290 patients with endometrial cancer were treated at the 1st Obstetrics and Gynecology Clinic of the University of Milan. The median age was 62 years. Surgery was completed in 262 (90.3%) patients. Abdominal hysterectomy was used in 158 (70.9%) stage I and 40 (71.4%) stage II/III patients; vaginal hysterectomy in 55 (24.7%) stage I and nine (16.1%) stage II/III patients. Resection of the upper vagina was performed in 168 patients. Postoperative external beam radiotherapy was used in stage II/III patients and in 44 (19.7%) stage I high-risk patients. Ten-year survival, determined by the life-table method, was 84.8% in stage I (223 patients), 53.4% in stage II (37 patients), 64.4% in stage III (19 patients), and 9.1% in stage IV (11 patients). Factors associated with poorer prognosis were: late age at diagnosis (P <0.001); deep myometrial invasion (P <0.001); poorly differentiated histological grade (P = 0.11); lack of resection of the upper vagina (P = 0.13). The role and importance of surgery is discussed, with special emphasis on the selective use of the vaginal route in aged, obese and medically high-risk patients.

Original languageEnglish
Pages (from-to)654-661
Number of pages8
JournalBritish Journal of Obstetrics and Gynaecology
Volume90
Issue number7
Publication statusPublished - Jul 1983

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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    Vecchia, C. L., Franceschi, S., Parazzini, F., Colombo, E., Colombo, F., Liberati, A., & Mangioni, C. (1983). Ten-year survival in 290 patients with endometrial cancer: prognostic factors and therapeutic approach. British Journal of Obstetrics and Gynaecology, 90(7), 654-661.