Tension pneumocephalus secondary to osteoradionecrosis of the clivus

Andrea Risso, Cesare Zoia, Carlo Gianformaggio, Fabio Pagella, Alessandro Pusateri, Marco Benazzo, Paolo Gaetani

Research output: Contribution to journalArticlepeer-review


We report the case of a 36 year-old man with relapsing undifferentiated nasopharyngealcarcinoma treated with a re-irradiation Cyberknife, who subsequently developed tensionpneumocephalus due to a cerebrospinal fluid leakage located at the clivus. The fistula wascaused by osteonecrosis of the skull base secondary to the tumor invasion and to the seque-lae of the radiotherapy. An endoscopic endonasal technique was used in order to repairthe defect, with a peduncolated nasoseptal flap harvested to perform the skull base recon-struction. In this paper, we discuss the importance of identifying this possible complicationrelated to radiotherapy in the management of neoplasm along the skull base; moreover, therole of endoscopy in the diagnosis and treatment of skull base fistulas is also described andcommented.

Original languageEnglish
Pages (from-to)71-75
Number of pages5
JournalReports of Practical Oncology and Radiotherapy
Issue number1
Publication statusPublished - Jan 1 2016


  • Endoscopic endonasal approach
  • Nasopharyngeal carcinoma (NPC)
  • Skull-base fistula
  • Tension pneumocephalus (TP)

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging


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