Abstract
Introduction: Immune dysfunction, promoted by pro-inflammatory cytokines, plays a pivotal role in neurodegeneration associated with Huntington's disease. Aims: The aim of this study was to investigate the emerging immunoregulatory and antiinflammatory properties of Sertoli cells in Huntington's disease. Methods: The experimental R6/2 mouse model of Huntington's disease was treated by a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells and lifespan, motor performance and striatal inflammatory pattern have been evaluated. Results: The results of this study demonstrated that a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells uniquely improved performances and extended the life expectancy of R6/2 Huntington's disease mice, by immune dysfunction modulation in brain. Conclusions: This study highlights the immunomodulatory and trophic role of Sertoli cells that could be of help in the treatment of neurodegenerative disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 686-690 |
| Number of pages | 5 |
| Journal | CNS Neuroscience and Therapeutics |
| Volume | 22 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 1 2016 |
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Keywords
- Cell transplant
- Inflammation
- Microcapsules
- Motor performance
ASJC Scopus subject areas
- Pharmacology (medical)
- Physiology (medical)
- Psychiatry and Mental health
- Pharmacology
Cite this
Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease. / Luca, G.; Bellezza, Ilaria; Arato, I.; Di Pardo, Alba; Mancuso, F.; Calvitti, M.; Falabella, Giulia; Bartoli, Sara; Maglione, Vittorio; Amico, Enrico; Favellato, Mariagrazia; Basta, G.; Bodo, Maria; Minelli, Alba; Calafiore, R.; Frati, Luigi; Squitieri, Ferdinando.
In: CNS Neuroscience and Therapeutics, Vol. 22, No. 8, 01.08.2016, p. 686-690.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease
AU - Luca, G.
AU - Bellezza, Ilaria
AU - Arato, I.
AU - Di Pardo, Alba
AU - Mancuso, F.
AU - Calvitti, M.
AU - Falabella, Giulia
AU - Bartoli, Sara
AU - Maglione, Vittorio
AU - Amico, Enrico
AU - Favellato, Mariagrazia
AU - Basta, G.
AU - Bodo, Maria
AU - Minelli, Alba
AU - Calafiore, R.
AU - Frati, Luigi
AU - Squitieri, Ferdinando
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Introduction: Immune dysfunction, promoted by pro-inflammatory cytokines, plays a pivotal role in neurodegeneration associated with Huntington's disease. Aims: The aim of this study was to investigate the emerging immunoregulatory and antiinflammatory properties of Sertoli cells in Huntington's disease. Methods: The experimental R6/2 mouse model of Huntington's disease was treated by a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells and lifespan, motor performance and striatal inflammatory pattern have been evaluated. Results: The results of this study demonstrated that a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells uniquely improved performances and extended the life expectancy of R6/2 Huntington's disease mice, by immune dysfunction modulation in brain. Conclusions: This study highlights the immunomodulatory and trophic role of Sertoli cells that could be of help in the treatment of neurodegenerative disorders.
AB - Introduction: Immune dysfunction, promoted by pro-inflammatory cytokines, plays a pivotal role in neurodegeneration associated with Huntington's disease. Aims: The aim of this study was to investigate the emerging immunoregulatory and antiinflammatory properties of Sertoli cells in Huntington's disease. Methods: The experimental R6/2 mouse model of Huntington's disease was treated by a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells and lifespan, motor performance and striatal inflammatory pattern have been evaluated. Results: The results of this study demonstrated that a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells uniquely improved performances and extended the life expectancy of R6/2 Huntington's disease mice, by immune dysfunction modulation in brain. Conclusions: This study highlights the immunomodulatory and trophic role of Sertoli cells that could be of help in the treatment of neurodegenerative disorders.
KW - Cell transplant
KW - Inflammation
KW - Microcapsules
KW - Motor performance
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UR - http://www.scopus.com/inward/citedby.url?scp=84977673688&partnerID=8YFLogxK
U2 - 10.1111/cns.12569
DO - 10.1111/cns.12569
M3 - Article
VL - 22
SP - 686
EP - 690
JO - CNS Neuroscience and Therapeutics
JF - CNS Neuroscience and Therapeutics
SN - 1755-5930
IS - 8
ER -