Abstract
Introduction: Immune dysfunction, promoted by pro-inflammatory cytokines, plays a pivotal role in neurodegeneration associated with Huntington's disease. Aims: The aim of this study was to investigate the emerging immunoregulatory and antiinflammatory properties of Sertoli cells in Huntington's disease. Methods: The experimental R6/2 mouse model of Huntington's disease was treated by a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells and lifespan, motor performance and striatal inflammatory pattern have been evaluated. Results: The results of this study demonstrated that a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells uniquely improved performances and extended the life expectancy of R6/2 Huntington's disease mice, by immune dysfunction modulation in brain. Conclusions: This study highlights the immunomodulatory and trophic role of Sertoli cells that could be of help in the treatment of neurodegenerative disorders.
Original language | English |
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Pages (from-to) | 686-690 |
Number of pages | 5 |
Journal | CNS Neuroscience and Therapeutics |
Volume | 22 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 1 2016 |
Keywords
- Cell transplant
- Inflammation
- Microcapsules
- Motor performance
ASJC Scopus subject areas
- Pharmacology (medical)
- Physiology (medical)
- Psychiatry and Mental health
- Pharmacology