Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease

G. Luca, Ilaria Bellezza, I. Arato, Alba Di Pardo, F. Mancuso, M. Calvitti, Giulia Falabella, Sara Bartoli, Vittorio Maglione, Enrico Amico, Mariagrazia Favellato, G. Basta, Maria Bodo, Alba Minelli, R. Calafiore, Luigi Frati, Ferdinando Squitieri

Research output: Contribution to journalArticle

Abstract

Introduction: Immune dysfunction, promoted by pro-inflammatory cytokines, plays a pivotal role in neurodegeneration associated with Huntington's disease. Aims: The aim of this study was to investigate the emerging immunoregulatory and antiinflammatory properties of Sertoli cells in Huntington's disease. Methods: The experimental R6/2 mouse model of Huntington's disease was treated by a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells and lifespan, motor performance and striatal inflammatory pattern have been evaluated. Results: The results of this study demonstrated that a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells uniquely improved performances and extended the life expectancy of R6/2 Huntington's disease mice, by immune dysfunction modulation in brain. Conclusions: This study highlights the immunomodulatory and trophic role of Sertoli cells that could be of help in the treatment of neurodegenerative disorders.

Original languageEnglish
Pages (from-to)686-690
Number of pages5
JournalCNS Neuroscience and Therapeutics
Volume22
Issue number8
DOIs
Publication statusPublished - Aug 1 2016

Fingerprint

Sertoli Cells
Huntington Disease
Intraperitoneal Injections
Swine
Corpus Striatum
Life Expectancy
Neurodegenerative Diseases
Anti-Inflammatory Agents
Cytokines
Brain
Therapeutics

Keywords

  • Cell transplant
  • Inflammation
  • Microcapsules
  • Motor performance

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Physiology (medical)
  • Psychiatry and Mental health
  • Pharmacology

Cite this

Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease. / Luca, G.; Bellezza, Ilaria; Arato, I.; Di Pardo, Alba; Mancuso, F.; Calvitti, M.; Falabella, Giulia; Bartoli, Sara; Maglione, Vittorio; Amico, Enrico; Favellato, Mariagrazia; Basta, G.; Bodo, Maria; Minelli, Alba; Calafiore, R.; Frati, Luigi; Squitieri, Ferdinando.

In: CNS Neuroscience and Therapeutics, Vol. 22, No. 8, 01.08.2016, p. 686-690.

Research output: Contribution to journalArticle

Luca, G, Bellezza, I, Arato, I, Di Pardo, A, Mancuso, F, Calvitti, M, Falabella, G, Bartoli, S, Maglione, V, Amico, E, Favellato, M, Basta, G, Bodo, M, Minelli, A, Calafiore, R, Frati, L & Squitieri, F 2016, 'Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease', CNS Neuroscience and Therapeutics, vol. 22, no. 8, pp. 686-690. https://doi.org/10.1111/cns.12569
Luca, G. ; Bellezza, Ilaria ; Arato, I. ; Di Pardo, Alba ; Mancuso, F. ; Calvitti, M. ; Falabella, Giulia ; Bartoli, Sara ; Maglione, Vittorio ; Amico, Enrico ; Favellato, Mariagrazia ; Basta, G. ; Bodo, Maria ; Minelli, Alba ; Calafiore, R. ; Frati, Luigi ; Squitieri, Ferdinando. / Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease. In: CNS Neuroscience and Therapeutics. 2016 ; Vol. 22, No. 8. pp. 686-690.
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