Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease

G. Luca; Ilaria Bellezza; I. Arato; Alba Di Pardo; F. Mancuso; M. Calvitti; Giulia Falabella; Sara Bartoli; Vittorio Maglione; Enrico Amico; Mariagrazia Favellato; G. Basta; Maria Bodo; Alba Minelli; R. Calafiore; Luigi Frati; Ferdinando Squitieri

doi:10.1111/cns.12569

Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease

G. Luca, Ilaria Bellezza, I. Arato, Alba Di Pardo, F. Mancuso, M. Calvitti, Giulia Falabella, Sara Bartoli, Vittorio Maglione, Enrico Amico, Mariagrazia Favellato, G. Basta, Maria Bodo, Alba Minelli, R. Calafiore, Luigi Frati, Ferdinando Squitieri

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: Immune dysfunction, promoted by pro-inflammatory cytokines, plays a pivotal role in neurodegeneration associated with Huntington's disease. Aims: The aim of this study was to investigate the emerging immunoregulatory and antiinflammatory properties of Sertoli cells in Huntington's disease. Methods: The experimental R6/2 mouse model of Huntington's disease was treated by a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells and lifespan, motor performance and striatal inflammatory pattern have been evaluated. Results: The results of this study demonstrated that a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells uniquely improved performances and extended the life expectancy of R6/2 Huntington's disease mice, by immune dysfunction modulation in brain. Conclusions: This study highlights the immunomodulatory and trophic role of Sertoli cells that could be of help in the treatment of neurodegenerative disorders.

Original language	English
Pages (from-to)	686-690
Number of pages	5
Journal	CNS Neuroscience and Therapeutics
Volume	22
Issue number	8
DOIs	https://doi.org/10.1111/cns.12569
Publication status	Published - Aug 1 2016

Keywords

Cell transplant
Inflammation
Microcapsules
Motor performance

ASJC Scopus subject areas

Pharmacology (medical)
Physiology (medical)
Psychiatry and Mental health
Pharmacology

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10.1111/cns.12569

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Luca, G., Bellezza, I., Arato, I., Di Pardo, A., Mancuso, F., Calvitti, M., Falabella, G., Bartoli, S., Maglione, V., Amico, E., Favellato, M., Basta, G., Bodo, M., Minelli, A., Calafiore, R., Frati, L., & Squitieri, F. (2016). Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease. CNS Neuroscience and Therapeutics, 22(8), 686-690. https://doi.org/10.1111/cns.12569

Luca, G, Bellezza, I, Arato, I, Di Pardo, A, Mancuso, F, Calvitti, M, Falabella, G, Bartoli, S, Maglione, V, Amico, E, Favellato, M, Basta, G, Bodo, M, Minelli, A, Calafiore, R, Frati, L & Squitieri, F 2016, 'Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease', CNS Neuroscience and Therapeutics, vol. 22, no. 8, pp. 686-690. https://doi.org/10.1111/cns.12569

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abstract = "Introduction: Immune dysfunction, promoted by pro-inflammatory cytokines, plays a pivotal role in neurodegeneration associated with Huntington's disease. Aims: The aim of this study was to investigate the emerging immunoregulatory and antiinflammatory properties of Sertoli cells in Huntington's disease. Methods: The experimental R6/2 mouse model of Huntington's disease was treated by a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells and lifespan, motor performance and striatal inflammatory pattern have been evaluated. Results: The results of this study demonstrated that a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells uniquely improved performances and extended the life expectancy of R6/2 Huntington's disease mice, by immune dysfunction modulation in brain. Conclusions: This study highlights the immunomodulatory and trophic role of Sertoli cells that could be of help in the treatment of neurodegenerative disorders.",

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AU - Luca, G.

AU - Bellezza, Ilaria

AU - Arato, I.

AU - Di Pardo, Alba

AU - Mancuso, F.

AU - Calvitti, M.

AU - Falabella, Giulia

AU - Bartoli, Sara

AU - Maglione, Vittorio

AU - Amico, Enrico

AU - Favellato, Mariagrazia

AU - Basta, G.

AU - Bodo, Maria

AU - Minelli, Alba

AU - Calafiore, R.

AU - Frati, Luigi

AU - Squitieri, Ferdinando

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Introduction: Immune dysfunction, promoted by pro-inflammatory cytokines, plays a pivotal role in neurodegeneration associated with Huntington's disease. Aims: The aim of this study was to investigate the emerging immunoregulatory and antiinflammatory properties of Sertoli cells in Huntington's disease. Methods: The experimental R6/2 mouse model of Huntington's disease was treated by a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells and lifespan, motor performance and striatal inflammatory pattern have been evaluated. Results: The results of this study demonstrated that a single intraperitoneal injection of microencapsulated prepubertal porcine Sertoli cells uniquely improved performances and extended the life expectancy of R6/2 Huntington's disease mice, by immune dysfunction modulation in brain. Conclusions: This study highlights the immunomodulatory and trophic role of Sertoli cells that could be of help in the treatment of neurodegenerative disorders.

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Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease

Abstract

Keywords

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