Teratogenic effects of antiepileptic drugs

Torbjörn Tomson; Dina Battino

doi:10.1016/S1474-4422(12)70103-5

Teratogenic effects of antiepileptic drugs

Torbjörn Tomson, Dina Battino

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article

Abstract

Most women with active epilepsy need treatment with antiepileptic drugs during pregnancy. Antiepileptic drugs are also frequently used for other indications, such as migraine, pain syndromes, and psychiatric disorders, which are prevalent among women of childbearing age. Possible teratogenic effects of antiepileptic drugs are therefore of wide concern and the risks imposed by the drugs must be weighed against the risks associated with the disorder being treated. Adverse drug effects on the fetus can present as fetal loss, intrauterine growth retardation, congenital malformations, impaired postnatal development, and behavioural problems. For optimum use of antiepileptic drugs in women of childbearing age and rational management of epilepsy during pregnancy, a thorough understanding of the teratogenic effects of antiepileptic drugs and knowledge of the differences in risks between various treatment options are needed.

Original language	English
Pages (from-to)	803-813
Number of pages	11
Journal	The Lancet Neurology
Volume	11
Issue number	9
DOIs	https://doi.org/10.1016/S1474-4422(12)70103-5
Publication status	Published - Sep 2012

ASJC Scopus subject areas

Clinical Neurology

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Tomson, T., & Battino, D. (2012). Teratogenic effects of antiepileptic drugs. The Lancet Neurology, 11(9), 803-813. https://doi.org/10.1016/S1474-4422(12)70103-5

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