Teratogenic effects of antiepileptic drugs

Torbjörn Tomson, Dina Battino

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Most women with active epilepsy need treatment with antiepileptic drugs during pregnancy. Antiepileptic drugs are also frequently used for other indications, such as migraine, pain syndromes, and psychiatric disorders, which are prevalent among women of childbearing age. Possible teratogenic effects of antiepileptic drugs are therefore of wide concern and the risks imposed by the drugs must be weighed against the risks associated with the disorder being treated. Adverse drug effects on the fetus can present as fetal loss, intrauterine growth retardation, congenital malformations, impaired postnatal development, and behavioural problems. For optimum use of antiepileptic drugs in women of childbearing age and rational management of epilepsy during pregnancy, a thorough understanding of the teratogenic effects of antiepileptic drugs and knowledge of the differences in risks between various treatment options are needed.

Original languageEnglish
Pages (from-to)803-813
Number of pages11
JournalThe Lancet Neurology
Volume11
Issue number9
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Anticonvulsants
Epilepsy
Pregnancy
Fetal Growth Retardation
Migraine Disorders
Pharmaceutical Preparations
Psychiatry
Fetus
Pain
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Teratogenic effects of antiepileptic drugs. / Tomson, Torbjörn; Battino, Dina.

In: The Lancet Neurology, Vol. 11, No. 9, 09.2012, p. 803-813.

Research output: Contribution to journalArticle

Tomson, Torbjörn ; Battino, Dina. / Teratogenic effects of antiepileptic drugs. In: The Lancet Neurology. 2012 ; Vol. 11, No. 9. pp. 803-813.
@article{f6409572ec984cc598364569345f12c0,
title = "Teratogenic effects of antiepileptic drugs",
abstract = "Most women with active epilepsy need treatment with antiepileptic drugs during pregnancy. Antiepileptic drugs are also frequently used for other indications, such as migraine, pain syndromes, and psychiatric disorders, which are prevalent among women of childbearing age. Possible teratogenic effects of antiepileptic drugs are therefore of wide concern and the risks imposed by the drugs must be weighed against the risks associated with the disorder being treated. Adverse drug effects on the fetus can present as fetal loss, intrauterine growth retardation, congenital malformations, impaired postnatal development, and behavioural problems. For optimum use of antiepileptic drugs in women of childbearing age and rational management of epilepsy during pregnancy, a thorough understanding of the teratogenic effects of antiepileptic drugs and knowledge of the differences in risks between various treatment options are needed.",
author = "Torbj{\"o}rn Tomson and Dina Battino",
year = "2012",
month = "9",
doi = "10.1016/S1474-4422(12)70103-5",
language = "English",
volume = "11",
pages = "803--813",
journal = "The Lancet Neurology",
issn = "1474-4422",
publisher = "Lancet Publishing Group",
number = "9",

}

TY - JOUR

T1 - Teratogenic effects of antiepileptic drugs

AU - Tomson, Torbjörn

AU - Battino, Dina

PY - 2012/9

Y1 - 2012/9

N2 - Most women with active epilepsy need treatment with antiepileptic drugs during pregnancy. Antiepileptic drugs are also frequently used for other indications, such as migraine, pain syndromes, and psychiatric disorders, which are prevalent among women of childbearing age. Possible teratogenic effects of antiepileptic drugs are therefore of wide concern and the risks imposed by the drugs must be weighed against the risks associated with the disorder being treated. Adverse drug effects on the fetus can present as fetal loss, intrauterine growth retardation, congenital malformations, impaired postnatal development, and behavioural problems. For optimum use of antiepileptic drugs in women of childbearing age and rational management of epilepsy during pregnancy, a thorough understanding of the teratogenic effects of antiepileptic drugs and knowledge of the differences in risks between various treatment options are needed.

AB - Most women with active epilepsy need treatment with antiepileptic drugs during pregnancy. Antiepileptic drugs are also frequently used for other indications, such as migraine, pain syndromes, and psychiatric disorders, which are prevalent among women of childbearing age. Possible teratogenic effects of antiepileptic drugs are therefore of wide concern and the risks imposed by the drugs must be weighed against the risks associated with the disorder being treated. Adverse drug effects on the fetus can present as fetal loss, intrauterine growth retardation, congenital malformations, impaired postnatal development, and behavioural problems. For optimum use of antiepileptic drugs in women of childbearing age and rational management of epilepsy during pregnancy, a thorough understanding of the teratogenic effects of antiepileptic drugs and knowledge of the differences in risks between various treatment options are needed.

UR - http://www.scopus.com/inward/record.url?scp=84865135028&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865135028&partnerID=8YFLogxK

U2 - 10.1016/S1474-4422(12)70103-5

DO - 10.1016/S1474-4422(12)70103-5

M3 - Article

VL - 11

SP - 803

EP - 813

JO - The Lancet Neurology

JF - The Lancet Neurology

SN - 1474-4422

IS - 9

ER -