Teratoma with a malignant somatic component in pediatric patients

The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience

Monica Terenziani, Paolo D'Angelo, Gianni Bisogno, Renata Boldrini, Giovanni Cecchetto, Paola Collini, Massimo Conte, Tina De Laurentis, Ilaria Ilari, Paolo Indolfi, Alessandro Inserra, Luigi Piva, Fortunato Siracusa, Filippo Spreafico, Paolo Tamaro, Margherita Lo Curto

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background. Teratoma with a malignant somatic component (TMSC) is rare but described in adults, whereas information on pediatric presentation is sparse. Procedure. The Associazione Italiana Ematologia Oncologia Pediatrica identified 14 cases of TMSC. Clinical files and pathology specimens were reviewed. Results. The series (9 female, 5 male) showed the following disease: testis (2), sacrococcygeal (3), ovary (3), retroperitoneum (3), mediastinum (2), and foot soft tissue (1). Distribution of the somatic component was: carcinoma (4), pancreatic neuroendocrine tumor (1), neuroblastoma (3), rhabdomyosarcoma (3), rhabdomyosarcoma plus liposarcoma, chondrosarcoma, neurogenic sarcoma (1), chondrosarcoma plus neuroectodermal sarcoma (1), malignant peripheral nerve sheath tumor (1). Three patients were in stage I, four in stage II, three in stage III, and four in stage IV. All but one patient underwent surgery and only females showed carcinoma components. Nine patients relapsed or progressed and eight died. Six patients are alive and disease-free. Two patients underwent complete resection and four were treated based on transformed histologies. Relapse-free and overall survival rates were 35.7% and 42.8%, respectively (median follow-up, 31 months). Conclusions. Prognosis for germ cell tumors (GCTs) containing MSC is worse than that for GCTs. The pediatric disease appears to be more heterogeneous in tumor site distribution and MSC histology than in adults. Our series suggests no effects of age, histology, or gender on outcome. Surgery has an essential role in localized disease, with complete resection highly desirable. Chemotherapy optimized for histology should include reagents directed to the somatic malignancy, if chemosensitive. Malignant GCT warrants GCT-directed chemotherapy.

Original languageEnglish
Pages (from-to)532-537
Number of pages6
JournalPediatric Blood and Cancer
Volume54
Issue number4
DOIs
Publication statusPublished - Apr 2010

Fingerprint

Teratoma
Germ Cell and Embryonal Neoplasms
Pediatrics
Histology
Chondrosarcoma
Rhabdomyosarcoma
Neurofibrosarcoma
Drug Therapy
Liposarcoma
Clinical Pathology
Neuroendocrine Tumors
Neurilemmoma
Mediastinum
Neuroblastoma
Sarcoma
Testis
Foot
Ovary
Neoplasms
Survival Rate

Keywords

  • Childhood
  • Germ cell tumors
  • Malignant transformation
  • Teratoma

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Teratoma with a malignant somatic component in pediatric patients : The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience. / Terenziani, Monica; D'Angelo, Paolo; Bisogno, Gianni; Boldrini, Renata; Cecchetto, Giovanni; Collini, Paola; Conte, Massimo; De Laurentis, Tina; Ilari, Ilaria; Indolfi, Paolo; Inserra, Alessandro; Piva, Luigi; Siracusa, Fortunato; Spreafico, Filippo; Tamaro, Paolo; Lo Curto, Margherita.

In: Pediatric Blood and Cancer, Vol. 54, No. 4, 04.2010, p. 532-537.

Research output: Contribution to journalArticle

Terenziani, Monica ; D'Angelo, Paolo ; Bisogno, Gianni ; Boldrini, Renata ; Cecchetto, Giovanni ; Collini, Paola ; Conte, Massimo ; De Laurentis, Tina ; Ilari, Ilaria ; Indolfi, Paolo ; Inserra, Alessandro ; Piva, Luigi ; Siracusa, Fortunato ; Spreafico, Filippo ; Tamaro, Paolo ; Lo Curto, Margherita. / Teratoma with a malignant somatic component in pediatric patients : The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience. In: Pediatric Blood and Cancer. 2010 ; Vol. 54, No. 4. pp. 532-537.
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abstract = "Background. Teratoma with a malignant somatic component (TMSC) is rare but described in adults, whereas information on pediatric presentation is sparse. Procedure. The Associazione Italiana Ematologia Oncologia Pediatrica identified 14 cases of TMSC. Clinical files and pathology specimens were reviewed. Results. The series (9 female, 5 male) showed the following disease: testis (2), sacrococcygeal (3), ovary (3), retroperitoneum (3), mediastinum (2), and foot soft tissue (1). Distribution of the somatic component was: carcinoma (4), pancreatic neuroendocrine tumor (1), neuroblastoma (3), rhabdomyosarcoma (3), rhabdomyosarcoma plus liposarcoma, chondrosarcoma, neurogenic sarcoma (1), chondrosarcoma plus neuroectodermal sarcoma (1), malignant peripheral nerve sheath tumor (1). Three patients were in stage I, four in stage II, three in stage III, and four in stage IV. All but one patient underwent surgery and only females showed carcinoma components. Nine patients relapsed or progressed and eight died. Six patients are alive and disease-free. Two patients underwent complete resection and four were treated based on transformed histologies. Relapse-free and overall survival rates were 35.7{\%} and 42.8{\%}, respectively (median follow-up, 31 months). Conclusions. Prognosis for germ cell tumors (GCTs) containing MSC is worse than that for GCTs. The pediatric disease appears to be more heterogeneous in tumor site distribution and MSC histology than in adults. Our series suggests no effects of age, histology, or gender on outcome. Surgery has an essential role in localized disease, with complete resection highly desirable. Chemotherapy optimized for histology should include reagents directed to the somatic malignancy, if chemosensitive. Malignant GCT warrants GCT-directed chemotherapy.",
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AU - D'Angelo, Paolo

AU - Bisogno, Gianni

AU - Boldrini, Renata

AU - Cecchetto, Giovanni

AU - Collini, Paola

AU - Conte, Massimo

AU - De Laurentis, Tina

AU - Ilari, Ilaria

AU - Indolfi, Paolo

AU - Inserra, Alessandro

AU - Piva, Luigi

AU - Siracusa, Fortunato

AU - Spreafico, Filippo

AU - Tamaro, Paolo

AU - Lo Curto, Margherita

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N2 - Background. Teratoma with a malignant somatic component (TMSC) is rare but described in adults, whereas information on pediatric presentation is sparse. Procedure. The Associazione Italiana Ematologia Oncologia Pediatrica identified 14 cases of TMSC. Clinical files and pathology specimens were reviewed. Results. The series (9 female, 5 male) showed the following disease: testis (2), sacrococcygeal (3), ovary (3), retroperitoneum (3), mediastinum (2), and foot soft tissue (1). Distribution of the somatic component was: carcinoma (4), pancreatic neuroendocrine tumor (1), neuroblastoma (3), rhabdomyosarcoma (3), rhabdomyosarcoma plus liposarcoma, chondrosarcoma, neurogenic sarcoma (1), chondrosarcoma plus neuroectodermal sarcoma (1), malignant peripheral nerve sheath tumor (1). Three patients were in stage I, four in stage II, three in stage III, and four in stage IV. All but one patient underwent surgery and only females showed carcinoma components. Nine patients relapsed or progressed and eight died. Six patients are alive and disease-free. Two patients underwent complete resection and four were treated based on transformed histologies. Relapse-free and overall survival rates were 35.7% and 42.8%, respectively (median follow-up, 31 months). Conclusions. Prognosis for germ cell tumors (GCTs) containing MSC is worse than that for GCTs. The pediatric disease appears to be more heterogeneous in tumor site distribution and MSC histology than in adults. Our series suggests no effects of age, histology, or gender on outcome. Surgery has an essential role in localized disease, with complete resection highly desirable. Chemotherapy optimized for histology should include reagents directed to the somatic malignancy, if chemosensitive. Malignant GCT warrants GCT-directed chemotherapy.

AB - Background. Teratoma with a malignant somatic component (TMSC) is rare but described in adults, whereas information on pediatric presentation is sparse. Procedure. The Associazione Italiana Ematologia Oncologia Pediatrica identified 14 cases of TMSC. Clinical files and pathology specimens were reviewed. Results. The series (9 female, 5 male) showed the following disease: testis (2), sacrococcygeal (3), ovary (3), retroperitoneum (3), mediastinum (2), and foot soft tissue (1). Distribution of the somatic component was: carcinoma (4), pancreatic neuroendocrine tumor (1), neuroblastoma (3), rhabdomyosarcoma (3), rhabdomyosarcoma plus liposarcoma, chondrosarcoma, neurogenic sarcoma (1), chondrosarcoma plus neuroectodermal sarcoma (1), malignant peripheral nerve sheath tumor (1). Three patients were in stage I, four in stage II, three in stage III, and four in stage IV. All but one patient underwent surgery and only females showed carcinoma components. Nine patients relapsed or progressed and eight died. Six patients are alive and disease-free. Two patients underwent complete resection and four were treated based on transformed histologies. Relapse-free and overall survival rates were 35.7% and 42.8%, respectively (median follow-up, 31 months). Conclusions. Prognosis for germ cell tumors (GCTs) containing MSC is worse than that for GCTs. The pediatric disease appears to be more heterogeneous in tumor site distribution and MSC histology than in adults. Our series suggests no effects of age, histology, or gender on outcome. Surgery has an essential role in localized disease, with complete resection highly desirable. Chemotherapy optimized for histology should include reagents directed to the somatic malignancy, if chemosensitive. Malignant GCT warrants GCT-directed chemotherapy.

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