Teratoma with somatic-type malignant components of the testis. A review and an update

Gregor Mikuz, Maurizio Colecchia

Research output: Contribution to journalArticlepeer-review

Abstract

Malignant transformation of germ cell tumors into somatic malignancy is uncommon. Its presentation differs from series to series, with 43 % of adult cases identified within the primary tumors and the remainder at the time of relapse or in the metastasis. Patients with stage I disease enjoy an excellent prognosis; whereas in metastatic sites when not completely resectable, the somatic type malignancies suffer a dismal prognosis. Radical surgery is significant for the prospects of cure and is standard chemotherapy for germ cell tumors; a transformation-oriented treatment can be effective for these patients. A deeper understanding of the biology of this phenomenon is essential for clinicians involved in such malignancies in order to permit a better control of the disease.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalVirchows Archiv
Volume461
Issue number1
DOIs
Publication statusPublished - Jul 2012

Keywords

  • Germ cell
  • Sarcoma
  • Somatic-type malignancy
  • Teratoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology
  • Molecular Biology

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