Terbuthylazine in hair as a biomarker of exposure

Rosa Mercadante; Elisa Polledri; Erminio Giavini; Elena Menegola; Pier Alberto Bertazzi; Silvia Fustinoni

doi:10.1016/j.toxlet.2011.11.018

Terbuthylazine in hair as a biomarker of exposure

Rosa Mercadante, Elisa Polledri, Erminio Giavini, Elena Menegola, Pier Alberto Bertazzi, Silvia Fustinoni

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Terbuthylazine (TBA) is an herbicide widely used in corn cultivation. Herein we evaluate the measurement of hair TBA as biomarkers of exposure. Five Sprague Dawley rats were gavaged with TBA for 3 days, and then the back hair was shaved and analyzed for TBA. In addition, head hair samples from 10 corn farmers, 9 rural residents, and 6 urban residents were collected at the end of the application season. Hair TBA was detected by liquid chromatography triple quadrupole mass spectrometry after solvent extraction. TBA was quantifiable in all rat samples with a mean concentration of 0.92 (±0.26). ng/mg, which corresponds to a 0.12% incorporation rate. TBA was quantifiable in all farmer samples (median: 0.67. ng/mg), in 75% of rural resident samples (0.01. ng/mg) and in none of the urban resident samples (

Original language	English
Pages (from-to)	169-173
Number of pages	5
Journal	Toxicology Letters
Volume	210
Issue number	2
DOIs	https://doi.org/10.1016/j.toxlet.2011.11.018
Publication status	Published - Apr 25 2012

Keywords

Biomonitoring
Desethylterbuthylazine
Exposure
Hair
Terbuthylazine

ASJC Scopus subject areas

Toxicology

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title = "Terbuthylazine in hair as a biomarker of exposure",

abstract = "Terbuthylazine (TBA) is an herbicide widely used in corn cultivation. Herein we evaluate the measurement of hair TBA as biomarkers of exposure. Five Sprague Dawley rats were gavaged with TBA for 3 days, and then the back hair was shaved and analyzed for TBA. In addition, head hair samples from 10 corn farmers, 9 rural residents, and 6 urban residents were collected at the end of the application season. Hair TBA was detected by liquid chromatography triple quadrupole mass spectrometry after solvent extraction. TBA was quantifiable in all rat samples with a mean concentration of 0.92 (±0.26). ng/mg, which corresponds to a 0.12% incorporation rate. TBA was quantifiable in all farmer samples (median: 0.67. ng/mg), in 75% of rural resident samples (0.01. ng/mg) and in none of the urban resident samples (",

keywords = "Biomonitoring, Desethylterbuthylazine, Exposure, Hair, Terbuthylazine",

author = "Rosa Mercadante and Elisa Polledri and Erminio Giavini and Elena Menegola and Bertazzi, {Pier Alberto} and Silvia Fustinoni",

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AU - Mercadante, Rosa

AU - Polledri, Elisa

AU - Giavini, Erminio

AU - Menegola, Elena

AU - Bertazzi, Pier Alberto

AU - Fustinoni, Silvia

PY - 2012/4/25

Y1 - 2012/4/25

N2 - Terbuthylazine (TBA) is an herbicide widely used in corn cultivation. Herein we evaluate the measurement of hair TBA as biomarkers of exposure. Five Sprague Dawley rats were gavaged with TBA for 3 days, and then the back hair was shaved and analyzed for TBA. In addition, head hair samples from 10 corn farmers, 9 rural residents, and 6 urban residents were collected at the end of the application season. Hair TBA was detected by liquid chromatography triple quadrupole mass spectrometry after solvent extraction. TBA was quantifiable in all rat samples with a mean concentration of 0.92 (±0.26). ng/mg, which corresponds to a 0.12% incorporation rate. TBA was quantifiable in all farmer samples (median: 0.67. ng/mg), in 75% of rural resident samples (0.01. ng/mg) and in none of the urban resident samples (

AB - Terbuthylazine (TBA) is an herbicide widely used in corn cultivation. Herein we evaluate the measurement of hair TBA as biomarkers of exposure. Five Sprague Dawley rats were gavaged with TBA for 3 days, and then the back hair was shaved and analyzed for TBA. In addition, head hair samples from 10 corn farmers, 9 rural residents, and 6 urban residents were collected at the end of the application season. Hair TBA was detected by liquid chromatography triple quadrupole mass spectrometry after solvent extraction. TBA was quantifiable in all rat samples with a mean concentration of 0.92 (±0.26). ng/mg, which corresponds to a 0.12% incorporation rate. TBA was quantifiable in all farmer samples (median: 0.67. ng/mg), in 75% of rural resident samples (0.01. ng/mg) and in none of the urban resident samples (

KW - Biomonitoring

KW - Desethylterbuthylazine

KW - Exposure

KW - Hair

KW - Terbuthylazine

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