Terguride in fluctuating parkinsonian patients: A double-blind study versus placebo

C. Pacchetti, E. Martignoni, P. Bruggi, L. Godi, B. Aufdembrinke, C. Miltenburger, B. Voet, G. Nappi

Research output: Contribution to journalArticle

Abstract

Terguride (TER), a semisynthetic derivative of lisuride, has been found to display dopamine (DA) agonist and DA antagonist effects in animals, depending on the experimental model used. TER (2 mg/day) was compared to placebo in 41 fluctuating Parkinson's disease patients to test its effect on akinesia and dyskinesia. Mean hours 'off' decreased at weeks 6 and 12 (p <0.05) in the TER group but the overall difference from the placebo group was not significant. Only the TER group displayed a decrease over time in mean Columbia University Rating Scale total score 'on' and 'off' (p = 0.001 and p = 0.03, respectively). Duration of involuntary movements and resulting disability were not significantly different between patients on TER and those on placebo administration. In the overall evaluation, patients preferred TER (p = 0.01). Tolerance of TER was very good in all but one patient whose wearing-off increased, no one dropped out because of side effects. This 3-month double-blind study showed that TER, added to stable doses of L-dopa, may have slight antiparkinsonian efficacy.

Original languageEnglish
Pages (from-to)463-465
Number of pages3
JournalMovement Disorders
Volume8
Issue number4
Publication statusPublished - 1993

Keywords

  • Long-term L-dopa syndrome
  • Parkinson's disease
  • Terguride

ASJC Scopus subject areas

  • Clinical Neurology

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