Terminal deoxynucleotidyl transferase in human lymphomas: Possible existence of forms with high and low molecular weights

P. Vezzoni, F. Campagnari, G. Di Fronzo, L. Clerici

Research output: Contribution to journalArticlepeer-review

Abstract

Optimized methods for extraction and enzyme assay in crude tissue preparations were used to determine the amounts of terminal deoxinucleotidyl tranferase (TdT) in malignant lymphomas. The TdT concentration was increased only in lymphoblastic lymphomas (LL) and was as high in these tumours as in the white blood cells from untreated patients with acute lymphoblastic leukaemia (ALL). The enzymes extracted from such lymphomas and from the leukaemic lymphoblasts had the same properties. Moreover, forms of TdT with low and high mol. wt were found in the LL tumours, similar to other reports of TdT-positive leukaemias. The overall study points at some basic biochemical identity of certain lymphoblastic malignancies, irrespective of whether the transformed cells are in solid tumours or are disseminated in the blood.

Original languageEnglish
Pages (from-to)312-319
Number of pages8
JournalBritish Journal of Cancer
Volume43
Issue number3
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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