Terminal deoxynucleotidyl transferase-positive acute leukemias evolving from a myelodysplastic syndrome

E. Brusamolino, P. Isernia, E. P. Alessandrino, A. I. Scovassi, U. Bertazzoni, C. Bernasconi

Research output: Contribution to journalArticlepeer-review

Abstract

We have analyzed the distribution of terminal deoxynucleotidyl transferase (TdT) in 30 patients with myelodysplastic syndromes (MDS), in connection with morphology, cytochemistry, and cytogenetics. All cases in preleukemic phase were strictly TdT-negative. At variance, 4 (19%) of 21 cases with subsequent leukemia were TdT-positive and showed a pure lymphoid (one case) or a mixed lymphoid-myelomonocytic (three cases) morphology. The TdT enzymatic activity ranged from 2 to 21 U/108 cells and the percent of positive cells in the immunofluorescence test ranged from 10 to 80% of total. All cases were Philadelphia chromosome-negative. The clonal origin of MDS from the pluripotent stem cell, capable of originating both a lymphoid and myeloid progeny, is further corroborated.

Original languageEnglish
Pages (from-to)187-190
Number of pages4
JournalAmerican Journal of Hematology
Volume20
Issue number2
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Hematology

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