Terminal deoxynucleotidyl transferase-positive B cell precursors in fetal lymph nodes and extrahemopoietic tissues

G. Cattoretti, C. Parravicini, A. Bonati, M. Buscaglia, G. Zuliani, A. Plebani, D. Delia, F. Rilke

Research output: Contribution to journalArticlepeer-review

Abstract

Terminal deoxynucleotidyl transferase (TdT)-positive B cell precursors populate fetal lymph nodes (LN) of mid-term (16th-22th week) fetuses. These cells have a B cell phenotype (HLA-DR, CD45R, CD22, μ) and lack mature differentiation antigens (CD1c, CD20, L26). TdT+ cells are also present in the extranodal mesenteric mesenchyme, pancreas and LN primordia. Extranodal TdT+ cells are found among proliferating (i.e. Ki-67+) B cells and lack leukocyte function-associated antigen (LFA-1) and HLA-DQ; these latter molecules are acquired by nodal TdT+ elements. Adult LN, adult and fetal spleen contain less TdT+ cells than fetal LN. The fetal LN contains the full range of the B cell differentiation compartment, from the TdT+ precursor cell to the mature B lymphocyte.

Original languageEnglish
Pages (from-to)493-500
Number of pages8
JournalEuropean Journal of Immunology
Volume19
Issue number3
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Immunology

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