Terminal deoxynucleotidyl transferase-positive B cell precursors in fetal lymph nodes and extrahemopoietic tissues

G. Cattoretti, C. Parravicini, A. Bonati, M. Buscaglia, G. Zuliani, A. Plebani, D. Delia, F. Rilke

Research output: Contribution to journalArticle

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Abstract

Terminal deoxynucleotidyl transferase (TdT)-positive B cell precursors populate fetal lymph nodes (LN) of mid-term (16th-22th week) fetuses. These cells have a B cell phenotype (HLA-DR, CD45R, CD22, μ) and lack mature differentiation antigens (CD1c, CD20, L26). TdT+ cells are also present in the extranodal mesenteric mesenchyme, pancreas and LN primordia. Extranodal TdT+ cells are found among proliferating (i.e. Ki-67+) B cells and lack leukocyte function-associated antigen (LFA-1) and HLA-DQ; these latter molecules are acquired by nodal TdT+ elements. Adult LN, adult and fetal spleen contain less TdT+ cells than fetal LN. The fetal LN contains the full range of the B cell differentiation compartment, from the TdT+ precursor cell to the mature B lymphocyte.

Original languageEnglish
Pages (from-to)493-500
Number of pages8
JournalEuropean Journal of Immunology
Volume19
Issue number3
Publication statusPublished - 1989

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B-Lymphoid Precursor Cells
DNA Nucleotidylexotransferase
Lymph Nodes
B-Lymphocytes
Lymphocyte Function-Associated Antigen-1
HLA-DQ Antigens
Differentiation Antigens
HLA-DR Antigens
Mesoderm
Cell Differentiation
Pancreas
Fetus
Spleen
Phenotype

ASJC Scopus subject areas

  • Immunology

Cite this

Cattoretti, G., Parravicini, C., Bonati, A., Buscaglia, M., Zuliani, G., Plebani, A., ... Rilke, F. (1989). Terminal deoxynucleotidyl transferase-positive B cell precursors in fetal lymph nodes and extrahemopoietic tissues. European Journal of Immunology, 19(3), 493-500.

Terminal deoxynucleotidyl transferase-positive B cell precursors in fetal lymph nodes and extrahemopoietic tissues. / Cattoretti, G.; Parravicini, C.; Bonati, A.; Buscaglia, M.; Zuliani, G.; Plebani, A.; Delia, D.; Rilke, F.

In: European Journal of Immunology, Vol. 19, No. 3, 1989, p. 493-500.

Research output: Contribution to journalArticle

Cattoretti, G, Parravicini, C, Bonati, A, Buscaglia, M, Zuliani, G, Plebani, A, Delia, D & Rilke, F 1989, 'Terminal deoxynucleotidyl transferase-positive B cell precursors in fetal lymph nodes and extrahemopoietic tissues', European Journal of Immunology, vol. 19, no. 3, pp. 493-500.
Cattoretti G, Parravicini C, Bonati A, Buscaglia M, Zuliani G, Plebani A et al. Terminal deoxynucleotidyl transferase-positive B cell precursors in fetal lymph nodes and extrahemopoietic tissues. European Journal of Immunology. 1989;19(3):493-500.
Cattoretti, G. ; Parravicini, C. ; Bonati, A. ; Buscaglia, M. ; Zuliani, G. ; Plebani, A. ; Delia, D. ; Rilke, F. / Terminal deoxynucleotidyl transferase-positive B cell precursors in fetal lymph nodes and extrahemopoietic tissues. In: European Journal of Immunology. 1989 ; Vol. 19, No. 3. pp. 493-500.
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