Terminology and classification of the cortical dysplasias

André Palmini, I. Najm, G. Avanzini, T. Babb, R. Guerrini, N. Foldvary-Schaefer, G. Jackson, H. O. Lüders, R. Prayson, R. Spreafico, H. V. Vinters

Research output: Contribution to journalArticle

Abstract

Background: There have been difficulties in achieving a uniform terminology in the literature regarding issues of classification with respect to focal cortical dysplasias (FCDs) associated with epilepsy. Objectives: To review and refine the current terminology and classification issues of potential clinical relevance to epileptologists, neuroradiologists, and neuropathologists dealing with FCD. Methods: A panel discussion of epileptologists, neuropathologists, and neuroradiologists with special expertise in FCD was held. Results: The panel proposed 1) a specific terminology for the different types of abnormal cells encountered in the cerebral cortex of patients with FCD; 2) a reappraisal of the different histopathologic abnormalities usually subsumed under the term "microdysgenesis," and suggested that this terminology be abandoned; and 3) a more detailed yet straightforward classification of the various histopathologic features that usually are included under the heterogeneous term of "focal cortical dysplasia." Conclusion: The panel hopes that these proposals will stimulate the debate toward more specific clinical, imaging, histopathologic, and prognostic correlations in patients with FCD associated with epilepsy.

Original languageEnglish
JournalNeurology
Volume62
Issue number6 SUPPL. 3
Publication statusPublished - Mar 23 2004

    Fingerprint

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Palmini, A., Najm, I., Avanzini, G., Babb, T., Guerrini, R., Foldvary-Schaefer, N., Jackson, G., Lüders, H. O., Prayson, R., Spreafico, R., & Vinters, H. V. (2004). Terminology and classification of the cortical dysplasias. Neurology, 62(6 SUPPL. 3).