Terpenoid treatment in osteoporosis: this is where we have come in research

Daniele Bellavia, Fabio Caradonna, Eufrosina Dimarco, Viviana Costa, Valeria Carina, Angela De Luca, Lavinia Raimondi, Carla Gentile, Riccardo Alessandro, Milena Fini, Gianluca Giavaresi

Research output: Contribution to journalReview articlepeer-review


Lower bone resistance to load is due to the imbalance of bone homeostasis, where excessive bone resorption, compared with bone formation, determines a progressive osteopenia, leading to a high risk of fractures and consequent pain and functional limitations. Terpenoids, with their activities against bone resorption, have recently received increased attention from researchers. They are potentially more suitable for long-term use compared with traditional therapeutics. In this review of the literature of the past 5 years, we provide comprehensive information on terpenoids, with their anti-osteoporotic effects, highlighting molecular mechanisms that are often in epigenetic key and a possible pharmacological use in osteoporosis prevention and treatment.

Original languageEnglish
Pages (from-to)846-861
Number of pages16
JournalTrends in Endocrinology and Metabolism
Issue number11
Early online dateSep 15 2021
Publication statusPublished - Nov 2021


  • bone erosive diseases
  • osteoblast
  • osteoclast
  • osteoporosis
  • terpenoids


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