Tertiary lymphoid tissue: A gateway for T cells in the tumor microenvironment

Giuseppe di Caro, Federica Marchesi

Research output: Contribution to journalArticlepeer-review


Tumor-infiltrating lymphocytes influence colorectal cancer progression. We have recently documented that tertiary lymphoid tissue in the colorectal cancer microenvironment orchestrates lymphocyte infiltration and that tertiary lymphoid tissue and lymphocytes cooperate in a coordinated antitumor immune response to improve patient outcome. Thus, tertiary lymphoid tissue represents a potential target in the design of tailored immune-based therapeutic approaches.

Original languageEnglish
Article numbere28850
Issue number5
Publication statusPublished - 2014


  • Biomarkers
  • Colorectal cancer
  • Immunotherapy
  • Prognosis
  • Tertiary lymphoid tissue
  • Tumor-infiltrating lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology


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