Tertiary lymphoid tissue: A gateway for T cells in the tumor microenvironment

Giuseppe di Caro; Federica Marchesi

doi:10.4161/onci.28850

Tertiary lymphoid tissue: A gateway for T cells in the tumor microenvironment

Giuseppe di Caro, Federica Marchesi

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Tumor-infiltrating lymphocytes influence colorectal cancer progression. We have recently documented that tertiary lymphoid tissue in the colorectal cancer microenvironment orchestrates lymphocyte infiltration and that tertiary lymphoid tissue and lymphocytes cooperate in a coordinated antitumor immune response to improve patient outcome. Thus, tertiary lymphoid tissue represents a potential target in the design of tailored immune-based therapeutic approaches.

Original language	English
Article number	e28850
Journal	OncoImmunology
Volume	3
Issue number	5
DOIs	https://doi.org/10.4161/onci.28850
Publication status	Published - 2014

Keywords

Biomarkers
Colorectal cancer
Immunotherapy
Prognosis
Tertiary lymphoid tissue
Tumor-infiltrating lymphocytes

ASJC Scopus subject areas

Immunology and Allergy
Oncology
Immunology

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10.4161/onci.28850

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