Tertiary lymphoid tissue: A gateway for T cells in the tumor microenvironment

Giuseppe di Caro; Federica Marchesi

doi:10.4161/onci.28850

Tertiary lymphoid tissue: A gateway for T cells in the tumor microenvironment

Giuseppe di Caro, Federica Marchesi

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Tumor-infiltrating lymphocytes influence colorectal cancer progression. We have recently documented that tertiary lymphoid tissue in the colorectal cancer microenvironment orchestrates lymphocyte infiltration and that tertiary lymphoid tissue and lymphocytes cooperate in a coordinated antitumor immune response to improve patient outcome. Thus, tertiary lymphoid tissue represents a potential target in the design of tailored immune-based therapeutic approaches.

Original language	English
Article number	e28850
Journal	OncoImmunology
Volume	3
Issue number	5
DOIs	https://doi.org/10.4161/onci.28850
Publication status	Published - 2014

Keywords

Biomarkers
Colorectal cancer
Immunotherapy
Prognosis
Tertiary lymphoid tissue
Tumor-infiltrating lymphocytes

ASJC Scopus subject areas

Immunology and Allergy
Oncology
Immunology

Access to Document

10.4161/onci.28850

Cite this

@article{8daeee71f3c0413d9a6a126f2431d1c6,

title = "Tertiary lymphoid tissue: A gateway for T cells in the tumor microenvironment",

abstract = "Tumor-infiltrating lymphocytes influence colorectal cancer progression. We have recently documented that tertiary lymphoid tissue in the colorectal cancer microenvironment orchestrates lymphocyte infiltration and that tertiary lymphoid tissue and lymphocytes cooperate in a coordinated antitumor immune response to improve patient outcome. Thus, tertiary lymphoid tissue represents a potential target in the design of tailored immune-based therapeutic approaches.",

keywords = "Biomarkers, Colorectal cancer, Immunotherapy, Prognosis, Tertiary lymphoid tissue, Tumor-infiltrating lymphocytes",

author = "{di Caro}, Giuseppe and Federica Marchesi",

year = "2014",

doi = "10.4161/onci.28850",

language = "English",

volume = "3",

journal = "OncoImmunology",

issn = "2162-4011",

publisher = "Taylor and Francis Inc.",

number = "5",

}

TY - JOUR

T1 - Tertiary lymphoid tissue

T2 - A gateway for T cells in the tumor microenvironment

AU - di Caro, Giuseppe

AU - Marchesi, Federica

PY - 2014

Y1 - 2014

N2 - Tumor-infiltrating lymphocytes influence colorectal cancer progression. We have recently documented that tertiary lymphoid tissue in the colorectal cancer microenvironment orchestrates lymphocyte infiltration and that tertiary lymphoid tissue and lymphocytes cooperate in a coordinated antitumor immune response to improve patient outcome. Thus, tertiary lymphoid tissue represents a potential target in the design of tailored immune-based therapeutic approaches.

AB - Tumor-infiltrating lymphocytes influence colorectal cancer progression. We have recently documented that tertiary lymphoid tissue in the colorectal cancer microenvironment orchestrates lymphocyte infiltration and that tertiary lymphoid tissue and lymphocytes cooperate in a coordinated antitumor immune response to improve patient outcome. Thus, tertiary lymphoid tissue represents a potential target in the design of tailored immune-based therapeutic approaches.

KW - Biomarkers

KW - Colorectal cancer

KW - Immunotherapy

KW - Prognosis

KW - Tertiary lymphoid tissue

KW - Tumor-infiltrating lymphocytes

UR - http://www.scopus.com/inward/record.url?scp=84904061703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904061703&partnerID=8YFLogxK

U2 - 10.4161/onci.28850

DO - 10.4161/onci.28850

M3 - Article

AN - SCOPUS:84904061703

VL - 3

JO - OncoImmunology

JF - OncoImmunology

SN - 2162-4011

IS - 5

M1 - e28850

ER -

Tertiary lymphoid tissue: A gateway for T cells in the tumor microenvironment

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this