Testicular microlithiasis: An unreported feature of McCune-Albright syndrome in males

Malgorzata Wasniewska, Filippo De Luca, Silvano Bertelloni, Patrizia Matarazzo, Giovanna Weber, Giuseppe Crisafulli, Mariella Valenzise, Roberto Lala

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To ascertain the incidence of testicular microlithiasis (TM) in boys with McCune-Albright syndrome (MAS). Study population consisted of 8 boys with MAS whose medical records were reviewed with emphasis on their past genitourinary histories. All of the boys underwent a clinical and ultrasonographic (US) scanning of the scrotal and inguinal regions. US results in boys with MAS were compared with those obtained in two control populations consisting of 20 healthy subjects and 12 boys with idiopathic and untreated central precocious puberty (CPP). Clinical examination revealed urological abnormalities in no patients, whereas US showed a typical picture of TM in 5 of 8 boys. TM was observed in none of the subjects belonging to control populations (v = 15.2 and 11.3, respectively; P <.001). In a series of 8 boys with MAS we demonstrated a high prevalence (62%) of TM that was associated with neither malignant nor nonmalignant conditions. This finding is unlikely to be only occasional, considering the very low prevalence of TM reported until now in healthy children and young adults and in our results in control populations. TM may be another marker for MAS.

Original languageEnglish
Pages (from-to)670-672
Number of pages3
JournalJournal of Pediatrics
Issue number5
Publication statusPublished - Nov 2004

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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