TY - JOUR
T1 - Testicular microlithiasis
T2 - An unreported feature of McCune-Albright syndrome in males
AU - Wasniewska, Malgorzata
AU - De Luca, Filippo
AU - Bertelloni, Silvano
AU - Matarazzo, Patrizia
AU - Weber, Giovanna
AU - Crisafulli, Giuseppe
AU - Valenzise, Mariella
AU - Lala, Roberto
PY - 2004/11
Y1 - 2004/11
N2 - To ascertain the incidence of testicular microlithiasis (TM) in boys with McCune-Albright syndrome (MAS). Study population consisted of 8 boys with MAS whose medical records were reviewed with emphasis on their past genitourinary histories. All of the boys underwent a clinical and ultrasonographic (US) scanning of the scrotal and inguinal regions. US results in boys with MAS were compared with those obtained in two control populations consisting of 20 healthy subjects and 12 boys with idiopathic and untreated central precocious puberty (CPP). Clinical examination revealed urological abnormalities in no patients, whereas US showed a typical picture of TM in 5 of 8 boys. TM was observed in none of the subjects belonging to control populations (v = 15.2 and 11.3, respectively; P <.001). In a series of 8 boys with MAS we demonstrated a high prevalence (62%) of TM that was associated with neither malignant nor nonmalignant conditions. This finding is unlikely to be only occasional, considering the very low prevalence of TM reported until now in healthy children and young adults and in our results in control populations. TM may be another marker for MAS.
AB - To ascertain the incidence of testicular microlithiasis (TM) in boys with McCune-Albright syndrome (MAS). Study population consisted of 8 boys with MAS whose medical records were reviewed with emphasis on their past genitourinary histories. All of the boys underwent a clinical and ultrasonographic (US) scanning of the scrotal and inguinal regions. US results in boys with MAS were compared with those obtained in two control populations consisting of 20 healthy subjects and 12 boys with idiopathic and untreated central precocious puberty (CPP). Clinical examination revealed urological abnormalities in no patients, whereas US showed a typical picture of TM in 5 of 8 boys. TM was observed in none of the subjects belonging to control populations (v = 15.2 and 11.3, respectively; P <.001). In a series of 8 boys with MAS we demonstrated a high prevalence (62%) of TM that was associated with neither malignant nor nonmalignant conditions. This finding is unlikely to be only occasional, considering the very low prevalence of TM reported until now in healthy children and young adults and in our results in control populations. TM may be another marker for MAS.
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U2 - 10.1016/j.jpeds.2004.06.083
DO - 10.1016/j.jpeds.2004.06.083
M3 - Article
C2 - 15520771
AN - SCOPUS:7444264668
VL - 145
SP - 670
EP - 672
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 5
ER -