Testing a cumulative and aggregate exposure model using biomonitoring studies and dietary records for Italian vineyard spray operators

Marc C. Kennedy, C. Richard Glass, Silvia Fustinoni, Angelo Moretto, Stefan Mandic-Rajcevic, Patrizia Riso, Aida Turrini, Hilko van der Voet, Michel T. Hetmanski, Richard J. Fussell, Jacob D. van Klaveren

Research output: Contribution to journalArticle

Abstract

The need for improved tools to estimate the cumulative and aggregate exposure to compounds such as plant protection products (PPPs) is recognised in the EU Regulation 1107/2009. A new model has been developed to estimate the exposure within a population to single compounds or compounds within a Cumulative Action Group, considering dietary and non-dietary sources and multiple exposure routes. To test the model a field study was carried out in Italy with operators applying tebuconazole fungicides, with measurements of dermal exposure collected. Whole urine samples were collected and analysed to provide values for the absorbed dose of tebuconazole, with duplicate diet samples collected and analysed as a measure of dietary exposures. The model provided predicted values of exposure for combined dietary and non-dietary routes of exposures which were compared to the measured absorbed dose values based on urinary analysis. The model outputs provided mean daily exposure values of 1.77 (±1.96) μg a.s./kg BW which are comparable to measured mean values from the biomonitoring field study of 1.73 (±1.31) μg a.s./kg BW. To supplement the limited measurement data available, comparisons against other models were also made and found to be comparable.

Original languageEnglish
Pages (from-to)45-53
Number of pages9
JournalFood and Chemical Toxicology
Volume79
DOIs
Publication statusPublished - May 1 2014

Fingerprint

aggregate exposure
cumulative exposure
exposure models
Diet Records
Environmental Monitoring
vineyards
Testing
exposure pathways
tebuconazole
absorbed dose
Italy
testing
Urine
Diet
Skin
dermal exposure
Fungicides
dietary exposure
Population
Nutrition

Keywords

  • Common assessment group
  • Consumer exposure
  • Occupational exposure
  • Probabilistic modelling

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Testing a cumulative and aggregate exposure model using biomonitoring studies and dietary records for Italian vineyard spray operators. / Kennedy, Marc C.; Glass, C. Richard; Fustinoni, Silvia; Moretto, Angelo; Mandic-Rajcevic, Stefan; Riso, Patrizia; Turrini, Aida; van der Voet, Hilko; Hetmanski, Michel T.; Fussell, Richard J.; van Klaveren, Jacob D.

In: Food and Chemical Toxicology, Vol. 79, 01.05.2014, p. 45-53.

Research output: Contribution to journalArticle

Kennedy, MC, Glass, CR, Fustinoni, S, Moretto, A, Mandic-Rajcevic, S, Riso, P, Turrini, A, van der Voet, H, Hetmanski, MT, Fussell, RJ & van Klaveren, JD 2014, 'Testing a cumulative and aggregate exposure model using biomonitoring studies and dietary records for Italian vineyard spray operators', Food and Chemical Toxicology, vol. 79, pp. 45-53. https://doi.org/10.1016/j.fct.2014.12.012
Kennedy, Marc C. ; Glass, C. Richard ; Fustinoni, Silvia ; Moretto, Angelo ; Mandic-Rajcevic, Stefan ; Riso, Patrizia ; Turrini, Aida ; van der Voet, Hilko ; Hetmanski, Michel T. ; Fussell, Richard J. ; van Klaveren, Jacob D. / Testing a cumulative and aggregate exposure model using biomonitoring studies and dietary records for Italian vineyard spray operators. In: Food and Chemical Toxicology. 2014 ; Vol. 79. pp. 45-53.
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