Testing growth hormone deficiency in adults

Enrico Gabellieri, Luca Chiovato, Mary Lage, Ana I. Castro, Felipe F. Casanueva

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Growth hormone deficiency (GHD) in adults is a recognized syndrome which is defined biochemically within an appropriate clinical context. Clinically, patients investigated for GHD should include those with signs and symptoms of hypothalamic-pituitary disease, those who have received cranial irradiation or tumor treatment and those with traumatic brain injury or subarachnoid hemorrhage. Patients with three or more pituitary hormone deficiencies and an IGF-I below the reference range do not require provocative testing. The other patients need a provocative test of GH secretory reserve for the diagnosis of GHD. Insulin tolerance test is considered the diagnostic test of choice, however, the GH-releasing hormone (GHRH) + arginine, the GHRH + growth hormone-releasing peptide and the glucagon stimulation tests are well validated alternative tests in adults. Cutoffs differ across tests and results may be influenced by gender, age, body mass index, and theassay reference preparation.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalFrontiers of Hormone Research
Volume38
DOIs
Publication statusPublished - 2010

Fingerprint

Growth Hormone
Traumatic Brain Hemorrhage
Hypothalamic Diseases
Traumatic Subarachnoid Hemorrhage
Hormones
Pituitary Diseases
Cranial Irradiation
Pituitary Hormones
Glucagon
Insulin-Like Growth Factor I
Routine Diagnostic Tests
Signs and Symptoms
Arginine
Reference Values
Body Mass Index
Insulin
Neoplasms
Therapeutics
Traumatic Brain Injury
gamma-aminobutyryl-2-methyltryptophyl-2-methyltryptophyl-2-methyltryptophyl-lysinamide

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Gabellieri, E., Chiovato, L., Lage, M., Castro, A. I., & Casanueva, F. F. (2010). Testing growth hormone deficiency in adults. Frontiers of Hormone Research, 38, 139-144. https://doi.org/10.1159/000318503

Testing growth hormone deficiency in adults. / Gabellieri, Enrico; Chiovato, Luca; Lage, Mary; Castro, Ana I.; Casanueva, Felipe F.

In: Frontiers of Hormone Research, Vol. 38, 2010, p. 139-144.

Research output: Contribution to journalArticle

Gabellieri, E, Chiovato, L, Lage, M, Castro, AI & Casanueva, FF 2010, 'Testing growth hormone deficiency in adults', Frontiers of Hormone Research, vol. 38, pp. 139-144. https://doi.org/10.1159/000318503
Gabellieri, Enrico ; Chiovato, Luca ; Lage, Mary ; Castro, Ana I. ; Casanueva, Felipe F. / Testing growth hormone deficiency in adults. In: Frontiers of Hormone Research. 2010 ; Vol. 38. pp. 139-144.
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